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Database: UniProt
Entry: F6YKT2_HORSE
LinkDB: F6YKT2_HORSE
Original site: F6YKT2_HORSE 
ID   F6YKT2_HORSE            Unreviewed;      2663 AA.
AC   F6YKT2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   13-FEB-2019, entry version 47.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSECAP00000007443};
GN   Name=ITPR3 {ECO:0000313|VGNC:VGNC:19196};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007443, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000007443, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007443,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000007443}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007443};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 9796.ENSECAP00000007443; -.
DR   PaxDb; F6YKT2; -.
DR   Ensembl; ENSECAT00000009732; ENSECAP00000007443; ENSECAG00000007328.
DR   VGNC; VGNC:19196; ITPR3.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   InParanoid; F6YKT2; -.
DR   OMA; SFYNLMT; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000002281; Chromosome 20.
DR   Bgee; ENSECAG00000007328; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2193   2218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2230   2248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2260   2280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2316   2341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2361   2383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2490   2513       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      114    174       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      175    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      233    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       91    111       {ECO:0000256|SAM:Coils}.
FT   COILED     2621   2648       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2663 AA;  303339 MW;  381B53B606A9BF6C CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG FVDDPFVVRP PPGALDTPLK IFREYCLFKV
     CPMNRYSAQK QYWKAKQTKQ DKEKIADVVL LQKLQHAAQM EQKQNDTENK KVHGDVVKYG
     SVIQLLHMKS NKYLTVNKRL PALLEKNAMR VTLDATGNEG SWLFIQPFWK LRSNGDNVVV
     GDKVILNPVN AGQPLHASNY ELSDNAGCKE VNSVNCNTSW KINLFMQFRD HLEEVLKGGD
     VVRLFHAEQE KFLTCDEYKG KLQVFLRTTL RQSATSATSS NALWEVEVVH HDPCRGGAGH
     WNGLYRFKHL ATGNYLAAEE NPSYKGDVSD PKAAGTGAQS RTGRRNAGEK IKYRLVAVPH
     GNDIASLFEL DPTTLQKTDS FVPRNSYVRL RHLCTNTWIQ STNVPIDVEE ERPIRLMLGT
     CPTKEDKEAF AIVSVPVSEI RDLDFANDAS SMLASAVEKL NEGFISQNDR RFVIQLLEDL
     VFFVSDVPNN GQNVLDITVT KPNRERQKLM REQNILKQIF GILKAPFRDK GGEGPLVRLE
     ELSDQKNAPY QHMFRLCYRV LRHSQEDYRK NQEHIAKQFG MMQSQIGYDI LAEDTITALL
     HNNRKLLEKH ITKTEVETFV SLVRKNREPR FLDYLSDLCV SNHIAIPVTQ ELICKCVLDP
     KNSDILIQTE LRPVKEMAQS HEYLSIEYSE EEVWLTWTDR NNEHHEKSVR QLAQEARAGN
     AHDENVLSYY RYQLKLFARM CLDRQYLAID EISQQLGVDL IFLCMADEML PFDLRASFCH
     LMLHVHVDRD PQELVTPVKF ARLWTEIPTA ITIKDYDSNL NASRDDKKNK FASTMEFVED
     YLNNVVSEAV PFANEEKNKL TFEVVSLAHN LIYFGFYSFS ELLRLTRTLL GIIDCAYEDP
     GGKNVRRSIQ GVGHMMSTMV LSRKQSVFGA PTLSAGAGAA EPLDRSKFEE NEDIVVMETK
     LKILEILQFI LNVRLDYRIS YLLSVFKKEF VEVFPMQDSG ADGTAPAFDS TTANMNLDRI
     GEQAEAMFGV GKTSSMLEVD DEGGRMFLRV LIHLTMHNYA PLVSGALQLL FKHFSQRQEA
     MHTFKQVQLL ISAQDVENYK VIRSELDRLR TMVEKSELWV DKKGSSKGEE AEVGAAKDKK
     ERPTDEEGFL PPPGEKSSEN YQIVKGILER LNKMCGVGEQ MRKKQQRLLK NMDAHKVMLD
     LLQIPYDKGD AKMMEILRYT HQFLQKFCAG NPGNQALLHK HLHLFLTPGL LEAETMQHIF
     LNNYQLCSEI SEPVLQHFVH LLATHGRHVQ YLDFLHTVIK AEGKYVKKCQ DMIMTELTNA
     GDDVVVFYND KASLAHLLDM MKAAREGVED HSPLMYHISL VDLLAACAEG KNVYTEIKCT
     SLLPLEDVVS VVTHEDCITE VKVAYVNFVN HCYVDTEVEM KEIYTSSHIW TLFENFTLDM
     ARVCSKREKR LADPTLEKYV LTVVLDTINA FFSSPFSENS TSLQTHQTIV VQLLQSTTRL
     LECPWLQQQH KGSVEACIRT LAMVAKGRAI SLPMDLDAHI SSLLSSGASC AAAAQRNASS
     YKSTTRAFPR VTPTANQWDY KNIIEKLQDI ITALEERLKP LVQAELSVLV DVLHWPELLF
     LEGSEAYQRC ESGGFLSKLI QHTKDLMESE EKLCVKVLRT LQQMLLKKTK YGDRGNQLRK
     MLLQNYLQNR KSSSRGDLPD PMGTGLDQDW SAIAATQCRL DKEGATKLVC DLITSTKNEK
     IFQESIGLAI RLLDGGNTEI QKSFYNLMIS DKKSERFFKV LHDRMKRAQQ ETKSTVAVNM
     SDLGSQPRED REPADPTIKG RVASFSMPGS PSRYSLGPSL RRGHEVGERV QSNEMGTSVL
     IMQPILRFLQ LLCENHNRDL QNFLRCQNNK TNYNLVCETL QFLDIMCGST TGGLGLLGLY
     INEDNVGLVT QTLETLTEYC QGPCHENQTC IVTHESNGID IITALILNDI GPLCKYRMDL
     VLQLKDNASK LLLALMESRH DSENAERILI SLRPQELVDV IKKAYLQEEE RENSEVSPRE
     VGHNIYILAL QLSRHNKQLQ HLLKPVKRIQ EEEAEGISSM LSLNNKQLSQ MLKSSAPAQE
     EEEDPLAYYE NHTSQIEIVR QDRSMEQIVF PVPGICQFLT EETKHRLFTT TEQDEQGSKV
     SDFFDQSSFL HNEMEWQRKL RSMPLIYWFS RRMTLWGSIS FNLAVFINII IAFFYPYVEG
     ASTGVLGSPL ISLLFWILIC FSIAALFTKR YSIRPLIVAL ILRSIYYLGI GPTLNILGAL
     NLTNKIVFVV SFVGNRGTFI RGYKAMVMDM EFLYHVGYIL TSVLGLFVHE LFYSILLFDL
     IYREETLFNV IKSVTRNGRS ILLTALLALI LVYLFSIVGF LFLKDDFILE VDRLPSNHSR
     ANPLGMPHGA ATFVGTCSGD KMECASGVSV PEVLEEDEEL DSTERACDTL LMCIVTVMNH
     GLRNGGGVGD ILRKPSKDES LFPARVVYDL LFFFIVIIIV LNLIFGVIID TFADLRSEKQ
     KKEEILKTTC FICGLERDKF DNKTVSFEEH IKFEHNMWNY LYFIVLVRVK NKTDYTGPES
     YVAQMIKNKN LDWFPRMRAM SLVSNEGEGE QNEIRILQDK LNSTMKLVSH LTTQLNELKE
     QMTEQRKRRQ RLGFVDVQNC MSR
//
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