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Database: UniProt
Entry: F6YMM5_HORSE
LinkDB: F6YMM5_HORSE
Original site: F6YMM5_HORSE 
ID   F6YMM5_HORSE            Unreviewed;       694 AA.
AC   F6YMM5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   10-OCT-2018, entry version 47.
DE   SubName: Full=Transglutaminase 3 {ECO:0000313|Ensembl:ENSECAP00000021268};
GN   Name=TGM3 {ECO:0000313|Ensembl:ENSECAP00000021268,
GN   ECO:0000313|VGNC:VGNC:24062};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021268, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000021268, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021268,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000021268}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021268};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   RefSeq; XP_001497639.1; XM_001497589.3.
DR   STRING; 9796.ENSECAP00000021268; -.
DR   PaxDb; F6YMM5; -.
DR   PRIDE; F6YMM5; -.
DR   Ensembl; ENSECAT00000025564; ENSECAP00000021268; ENSECAG00000023860.
DR   GeneID; 100053068; -.
DR   KEGG; ecb:100053068; -.
DR   CTD; 7053; -.
DR   VGNC; VGNC:24062; TGM3.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; F6YMM5; -.
DR   KO; K05620; -.
DR   OMA; KADNMIR; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000002281; Chromosome 22.
DR   Bgee; ENSECAG00000023860; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:Ensembl.
DR   GO; GO:0043163; P:cell envelope organization; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:Ensembl.
DR   GO; GO:0051262; P:protein tetramerization; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN      266    358       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    274    274       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    332    332       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    355    355       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       395    395       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       397    397       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       445    445       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       450    450       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   694 AA;  76924 MW;  1A0972F5211414B0 CRC64;
     MSALEPQSIN WQMTSNRRAH NTHNFYDQEL ILRRGQAFNF LLSLNRNLSS GERLGFIAST
     GPNASESAKT KAVFPLSNSG SGGGWSAQLV SSQDKVLTIS ILTPANAPIG LYTLNLQIFS
     HGKEFTLKLG TFILLFNPWL QADSVFMSNR AEREEYVQED AGIIYVGSAN RIGMMGWNFG
     QFEEGILNIS LAVLDHSLNF RRDPATDVAR RSDPKYVGRV LSAMINGNDD NGVISGNWSG
     DYSGGRDPRN WNGSVEILKA WKSSGFRPVR FGQCWVFAGT LNTVLRSLGI PARVITNFNS
     AHDTDGNLSV DVYYDPMGNP LDKGRDSVWN FHVWNEAWFV RTDLGPSYNG WQVLDATPQE
     RSQGVFQCGP ASVFGVREGD VDKDFDMPFV FAEVNADRIT WIYDAYTGTQ KQSSSDSRSV
     GKYISTKAVG SSSRVDVTEK YKYPEGSSQE RQVFGKALGK LKPRVSFGAT SAGSVESEEQ
     TPSISGTFKV AGILEVGREV NLALLLKNLT DDVKTVSVNM TAWTIVYNGT LIHEVWKDSV
     TISLDPKEEK RHPVKISYAQ YEKYLKADNM IRTTAVCQVT DEPEVVVERD VILDNPTLTL
     EVLDEVRVQK PVHVQMLFSN PLDEPVKNCV LLVEGSGLLL GSLKIDVPAL RPKERSRVRF
     EILPTRSGTK QLLADFSCDK FPAIKAMLSI DVAE
//
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