ID F6YPP4_HORSE Unreviewed; 216 AA.
AC F6YPP4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA replication complex GINS protein PSF3 {ECO:0000256|RuleBase:RU367161};
GN Name=GINS3 {ECO:0000313|Ensembl:ENSECAP00000019679.2,
GN ECO:0000313|VGNC:VGNC:18343};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019679.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000019679.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019679.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000019679.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019679.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBUNIT: Component of the GINS complex.
CC {ECO:0000256|RuleBase:RU367161}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367161}.
CC -!- SIMILARITY: Belongs to the GINS3/PSF3 family.
CC {ECO:0000256|ARBA:ARBA00006343, ECO:0000256|RuleBase:RU367161}.
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DR RefSeq; XP_001494549.2; XM_001494499.4.
DR AlphaFoldDB; F6YPP4; -.
DR SMR; F6YPP4; -.
DR STRING; 9796.ENSECAP00000019679; -.
DR PaxDb; 9796-ENSECAP00000019679; -.
DR Ensembl; ENSECAT00000023735.4; ENSECAP00000019679.2; ENSECAG00000022245.4.
DR GeneID; 100063174; -.
DR KEGG; ecb:100063174; -.
DR CTD; 64785; -.
DR VGNC; VGNC:18343; GINS3.
DR GeneTree; ENSGT00390000001622; -.
DR HOGENOM; CLU_081646_2_0_1; -.
DR InParanoid; F6YPP4; -.
DR OMA; IYKEGWR; -.
DR OrthoDB; 3670282at2759; -.
DR TreeFam; TF314626; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000022245; Expressed in bone marrow and 23 other cell types or tissues.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IBA:GO_Central.
DR CDD; cd11713; GINS_A_psf3; 1.
DR CDD; cd21693; GINS_B_Psf3; 1.
DR Gene3D; 1.20.58.2050; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR010492; GINS_Psf3.
DR InterPro; IPR038437; GINS_Psf3_sf.
DR PANTHER; PTHR22768:SF0; DNA REPLICATION COMPLEX GINS PROTEIN PSF3; 1.
DR PANTHER; PTHR22768; UNCHARACTERIZED; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367161};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 67..173
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
SQ SEQUENCE 216 AA; 24446 MW; 6419B96422B12F07 CRC64;
MSEAYFRVES GALGPEENFL SLDDILMSHE KLPVRTETPI PRLGTFFLDR SGGAESDNAI
PEGSKLELPL WLAKGLFDNK RRILSVELPK IYQEGWRTVF SADANVVDLH KMGPHFYGFG
SQLLHFDSPE NADISQSLLQ TFIGRFRRIM DSSQNAYNED TSALVARLDE MERGLFQTGQ
KGLNDFQGWE KGQASQITAS SLVQNYKKRK FTDMED
//
