ID F6YQC8_CALJA Unreviewed; 454 AA.
AC F6YQC8; U3F066;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha {ECO:0000256|ARBA:ARBA00040625};
GN Name=CNTFR {ECO:0000313|Ensembl:ENSCJAP00000016006.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000016006.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000016006.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000016006.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000256|ARBA:ARBA00010890}.
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DR AlphaFoldDB; F6YQC8; -.
DR Ensembl; ENSCJAT00000016912.5; ENSCJAP00000016006.4; ENSCJAG00000008660.5.
DR eggNOG; ENOG502QUDK; Eukaryota.
DR GeneTree; ENSGT00940000158864; -.
DR HOGENOM; CLU_047259_0_0_1; -.
DR OMA; KICDTGE; -.
DR TreeFam; TF331210; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000008660; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IEA:Ensembl.
DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IEA:Ensembl.
DR GO; GO:0004897; F:ciliary neurotrophic factor receptor activity; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0003360; P:brainstem development; IEA:Ensembl.
DR GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0007548; P:sex differentiation; IEA:Ensembl.
DR GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl.
DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR23036:SF21; CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 109..171
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 288..388
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 49111 MW; 9CAA4D9422206DF6 CRC64;
MGEGRREGAR EGGRRMGGLK PRAPRSRCRA GGGGSGGGGS SRRGSGLRGG IRRAVLAPRS
LSCSLPEAVG RRGAKHWWPE GAMAAPVPWA CCAVLAAAAA VVYTQRHSPQ EAPHVQYERL
GSDVTLPCGT ANWDAAVTWR VNGTDLAPDL LNGSQLVLRG LELGHSGLYA CFHRDSWHLR
HQVLLHVGLP PREPVLSCRS NTYPKGFYCN WHLPTPTYIP NTFNVTVLHG SKIMVCEKDP
ALKNRCHIRY MHLFSTIKYK VSISVSNALG HNATAITFDE FTIVKPDPPE NVVARPVPSN
PRRLEVTWQT PSTWPDPESF PLKFFLRYRP LILDQWQHVE LSDGTAHTIT DAYAGKEYII
QVAAKDNEIG TWSDWSVAAH ATPWTEEPRH LTTEAQAAET TTSTTGSLAP PPTTKICDPG
ELGSGGGPSA PFLVSVPVTL ALAAAAATAS NLLI
//
