GenomeNet

Database: UniProt
Entry: F6YQS1_MACMU
LinkDB: F6YQS1_MACMU
Original site: F6YQS1_MACMU 
ID   F6YQS1_MACMU            Unreviewed;      1546 AA.
AC   F6YQS1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   03-JUL-2019, entry version 64.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000000634};
GN   Name=ARAP3 {ECO:0000313|Ensembl:ENSMMUP00000000634,
GN   ECO:0000313|VGNC:VGNC:69893};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000000634, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000000634, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000000634,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000000634}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000000634};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; JSUE03037096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03037097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014996571.1; XM_015141085.1.
DR   RefSeq; XP_014996572.1; XM_015141086.1.
DR   STRING; 9544.ENSMMUP00000000634; -.
DR   Ensembl; ENSMMUT00000000685; ENSMMUP00000000634; ENSMMUG00000000465.
DR   GeneID; 701400; -.
DR   KEGG; mcc:701400; -.
DR   CTD; 64411; -.
DR   VGNC; VGNC:69893; ARAP3.
DR   eggNOG; KOG1117; Eukaryota.
DR   eggNOG; COG5347; LUCA.
DR   GeneTree; ENSGT00940000158869; -.
DR   InParanoid; F6YQS1; -.
DR   KO; K12490; -.
DR   OrthoDB; 98944at2759; -.
DR   TreeFam; TF105769; -.
DR   Proteomes; UP000006718; Chromosome 6.
DR   Bgee; ENSMMUG00000000465; Expressed in 14 organ(s), highest expression level in lung.
DR   ExpressionAtlas; F6YQS1; baseline.
DR   GO; GO:0001726; C:ruffle; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 3.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 3.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN        8     68       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   DOMAIN      287    379       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      394    483       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      480    611       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      909   1090       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN     1119   1212       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     1225   1327       PH. {ECO:0000259|PROSITE:PS50003}.
FT   REGION       64    149       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
FT   REGION      170    194       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
FT   REGION      213    269       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
FT   REGION     1424   1546       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
FT   COMPBIAS     68     84       Polar. {ECO:0000256|MobiDB-lite:F6YQS1}.
FT   COMPBIAS    174    189       Polar. {ECO:0000256|MobiDB-lite:F6YQS1}.
FT   COMPBIAS    221    245       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
FT   COMPBIAS    255    269       Polar. {ECO:0000256|MobiDB-lite:F6YQS1}.
FT   COMPBIAS   1424   1460       Polar. {ECO:0000256|MobiDB-lite:F6YQS1}.
FT   COMPBIAS   1475   1489       Polar. {ECO:0000256|MobiDB-lite:F6YQS1}.
FT   COMPBIAS   1512   1546       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                F6YQS1}.
SQ   SEQUENCE   1546 AA;  170161 MW;  FE691CAC87DFFD01 CRC64;
     MAAPQDLDIA VWLATVHLEQ YADTFRRHGL ATAGAARGLG HEELKQLGIS ATGHRKRILR
     LLQTGTEEGS LDPKSDSAME PSSSPAPQTQ PPKPVPKPRT VFGGLSGPAT TQRPGLSPVL
     GEPGVSRSPE PSPRPPPLPT SSTEQSSALN TVEMMPNSIY FGLDLRGRAQ AAQEKAPDSS
     QTTAPTPALR PTAGTVHIMD PGCLYYGVQP VGTPGAPDRR EGRSVCQDRA EHRLSRQDLE
     AREDAGYASL ELPGDSTLLS PTLETEETSD DLISPYASFS FTADRPTPLL SGWLDKLSPQ
     GNYVFQRRFV QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV ITGQRVFVFR
     TESEAQRDTW CSTLQSCLKE QRLLGHPRPP QPPRPLRTGM LELRGHKAKV FAALSPGELA
     LYKSEQAFSL GIGICFIELQ GCSVRETKSR SFDLLTPHRC FSFTAESGGA RQSWAAALQE
     AVTETLSDYE VAEKIWSNRA NRHCADCGSS RPDWAAVNLG VVICKQCAGQ HRALGSGISK
     VQSLKLDTSV WSNEIVQLFI VLGNDRANRF WAGTLPPGEG LHPDATPGLR GEFISRKYRL
     GLFRKPHPQY PDHSQLLQAL CAAVAGPNLL KNMTQLLCVE AFEGEEPWSP PALDGSCPGL
     VPPDPSPGVY NEVVVPATYS GFLYCGPVTN KAGPSPPRRG RDAPPRLWCV LGAALEMFAS
     ENSPEPLSLI QPQDIVCLGV SPPPTDPGDL DRFPFSFELI LTGGRIQHFG TDGADSLEAW
     TSAVGKWFSP LSCHQLLGPG LLRLGRLWLR SPSHTAPAPG VWLSGFGLLR GDHLFLCSAP
     GPGPPAPEDM VHLRRLQEIS VVSAADTPDK KEYLVLVETG RTLYLQGEGR LDFTAWNTAI
     GGAAGGGGTG LQEQQMSRGD IPIIVDACIS FVTQHGLRLE GVYRKGGARA RSLKLLAEFR
     RDARSVKLRP GEHFVEDVTD TLKRFFRELD DPVTSARLLP RWREAAELPQ KNQRLQKYKD
     VIGCLPRVNR RTLATLIGHL YRVQKCAALN QMCTRNLALL FAPSVFQTDG RGEHEVRVLQ
     ELIDGYISVF DIDSDQVAQI DLEVSLITTW KDVQLSQAGD LIMEVYIEQQ LPDNCVTLKV
     SPTLTAEELT NQVLEMRGTA AGMDLWVTFE IREHGELERP LHPKEKVLEQ ALQWCQLPEP
     CSASLLLKKV PLAQAGCLFT GIRRESPRVG LLRCREEPPR LLGSRFQERF FLLRGRCLLL
     LKEKKSSKPE REWPLEGAKV FLGIRKKLKP PTPWGFTLIL EKMHLYLSCT DEDEMWDWTT
     SILKAQHDDQ QPVVLRRRSS SDLARQKFGT MPLLPIRGDD SGATLLSANQ TLRQLHNRRT
     LSMFFPMKSS QGSVEEQEEL EEPVYEEPVY EEVGAFPELT LDTSTSFSTT REWTVKPENP
     LTSQKSLDQP FLSKSSTLGQ EERPPEPPPG PLSKSSPQAR GSLEEQLLQE LSSLILRKGE
     TTAGLRSPSQ PSSPQSPSPT GLPTQTPGFP TQPPCISSPP SSHPLT
//
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