ID F6YQX0_XENTR Unreviewed; 902 AA.
AC F6YQX0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Exocyst complex component 2 {ECO:0000256|ARBA:ARBA00017526, ECO:0000256|RuleBase:RU365069};
GN Name=exoc2 {ECO:0000313|Ensembl:ENSXETP00000024907};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000024907};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000024907}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000024907};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000024907}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|ARBA:ARBA00002660, ECO:0000256|RuleBase:RU365069}.
CC -!- SUBUNIT: Component of the exocyst complex.
CC {ECO:0000256|RuleBase:RU365069}.
CC -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000256|ARBA:ARBA00010578,
CC ECO:0000256|RuleBase:RU365069}.
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DR AlphaFoldDB; F6YQX0; -.
DR Ensembl; ENSXETT00000024907; ENSXETP00000024907; ENSXETG00000011411.
DR AGR; Xenbase:XB-GENE-953993; -.
DR Xenbase; XB-GENE-953993; exoc2.
DR eggNOG; KOG2347; Eukaryota.
DR HOGENOM; CLU_005811_0_0_1; -.
DR TreeFam; TF105891; -.
DR Bgee; ENSXETG00000011411; Expressed in ovary and 14 other cell types or tissues.
DR ExpressionAtlas; F6YQX0; baseline.
DR GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR029175; EXOC2/Sec5.
DR InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR13043:SF1; EXOCYST COMPLEX COMPONENT 2; 1.
DR PANTHER; PTHR13043; EXOCYST COMPLEX COMPONENT SEC5; 1.
DR Pfam; PF15469; Sec5; 1.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU365069};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365069};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365069}.
FT DOMAIN 8..89
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|Pfam:PF01833"
FT DOMAIN 133..892
FT /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15469"
FT REGION 407..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 101022 MW; E87DC8AC6990C9ED CRC64;
MSKARQPPLV TGISPKEGTS WTKVTIRGEN LGTGPSDLIG LTICGHNCLL TAEWISASKI
VCRVGQDKND KGDIIVTTKS GGKGTSTVFF KLLKPDKIGI LDQSAVWVEE MNYYDTRTDR
NKGISPLSQR TANPLGIEID KQKIQSQAIE SLFPGMSGDF NCENFSATSY LITNHSTASF
EQLKTAANNL RKQASKKNEG NVAYVKGGLS TFFEAQDALA AIHQKLEADG TEKVEGSMTQ
VLEKVLKSAS TTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI EKNIQKGDYD
VVINDYEKAK SLFGKTEVQV FKKVYAEVET RIESLRNLLL DKLLETPSTL HDQKRYIRYL
SDLHAPGDPA WQCIGAQHKW IVQLMHSCKE GYVKELKGTP VLQSPLLDID SDGRPSPLGR
LSQNTSLQRG SSFQSGRNDT WRYKTPHQVS FVDKLTKVVV GQLPNFWKLW ISYVNGSLFS
EKMIQDVMQT LVKLIRGALL PFSLEEEELK HFGGWEVKSE LFGPWLMHVV QTVRLSHESL
TALEIPNDML QTIQDLILDL RVRCVMVTLQ HATEEVKRLA DKEDWIVDNE GLTSLPSQFE
QCIIQALQSL KGVIECKPGE TSIFQQQRIQ DDLCYLCINL IQVFITSLEY LSTKPAGGVD
IMHISADVSS PDLFGSIHED TTVSPEKRLL IVLSNCHFIE RHTLLNIAEH FEKYGFQAIE
KITRASTDSL KELDFRLFEC YIENKADPIV GSLEPGIYAG YFDWKDCPTP TGVRNYLKEA
LVNIIAVHAE VFAVSKELVP RVMARIVEAV GDELSRLMQC VSSFSRNGAL QARLELYALR
DAIAIYLTND SKSSFKHAVE ALPQLPSGSD KKLLEELLNE FKSSMHLQLT CFQSSSSVSL
KT
//
