ID F6YR15_MONDO Unreviewed; 713 AA.
AC F6YR15;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000001261.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000001261.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000001261.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YR15; -.
DR STRING; 13616.ENSMODP00000001261; -.
DR Ensembl; ENSMODT00000001288.2; ENSMODP00000001261.2; ENSMODG00000001063.2.
DR eggNOG; ENOG502RXF3; Eukaryota.
DR GeneTree; ENSGT00940000162411; -.
DR HOGENOM; CLU_022539_0_0_1; -.
DR InParanoid; F6YR15; -.
DR OMA; TRHGWQD; -.
DR TreeFam; TF336953; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000001063; Expressed in adult mammalian kidney and 15 other cell types or tissues.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IBA:GO_Central.
DR GO; GO:0002735; P:positive regulation of myeloid dendritic cell cytokine production; IBA:GO_Central.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.780; -; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR046946; TCAM1/2.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR040886; TRIF_N.
DR PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR PANTHER; PTHR47230:SF1; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR Pfam; PF17798; TRIF-NTD; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 408..566
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 170..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 78094 MW; FFE0581D19E851DC CRC64;
MAELIPSFRG VFDILSQAGQ DKLLYLKHKL KTSRPGTKAK DLLYAMILLT LGQETEARIC
LDSLKGDKAS LSVVRTWEGG EPLLNQADHL ASEDQADIQL TVARIYQLLL EENLCEASSR
NKAYKAALQA FRLGQDAQLD IMAEAQDLCG HDIHGAGSFQ TLRSDRSCFP GSSASASRVN
SHPVPISTRS SRLAAESSPQ SLHSTGSPAS FASVLEISQS PTLPFLTYQP QKRSHRGPSK
LCGDPHSNSA QDPAPQTSQE LEEINLSSSH PVASLHEQPD SLASVVSDPQ PPNPSISPPL
ITPVDPETSL HSSTECSEAL SDTQSLQPAS GKPSEALISK ESSGLLPGLP PMSVPPVGEG
EPTQFSVQES NCSEEVSDLN PPLSTQDPSP SPLSSSLISG PELDTGQRFF SFVVLHAQED
EAIALRVRDT LESLGVPDGA TFCEEFQVPG HFELRCLQDA IDNSAFTLLL LTRHFNCAMS
LHQVHMALMN SITRKNKKNS VIPFRPRESK LKSTEVSQLL SGLVILDESS PVFSRKVNNT
FNPRMLKAQR EAWKKEQEIR AIHKQTQQIV EDRENISKKH SALFDYAYNY NLLHQQLQTL
NLAFPNQAPF VQGYNMPLMY PWQPAFSPQV PTAPSAFHPN QFVPPMPFQH GSGSAAQPDP
QGAGAQPLII HNAHMLCPTH HDSIWGFLGK DTGMVCHFLL QLILQRRKLR QTG
//
