ID F6YRB8_XENTR Unreviewed; 629 AA.
AC F6YRB8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSXETP00000012912};
DE SubName: Full=Plasma kallikrein {ECO:0000313|RefSeq:XP_002934450.3, ECO:0000313|RefSeq:XP_004911242.2};
GN Name=klkb1 {ECO:0000313|Ensembl:ENSXETP00000012912,
GN ECO:0000313|RefSeq:XP_002934450.3, ECO:0000313|RefSeq:XP_004911242.2,
GN ECO:0000313|Xenbase:XB-GENE-985051};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000012912};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000012912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000012912};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000012912}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002934450.3, ECO:0000313|RefSeq:XP_004911242.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002934450.3,
RC ECO:0000313|RefSeq:XP_004911242.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002934450.3,
RC ECO:0000313|RefSeq:XP_004911242.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_002934450.3; XM_002934404.5.
DR RefSeq; XP_004911242.2; XM_004911185.4.
DR STRING; 8364.ENSXETP00000012912; -.
DR Ensembl; ENSXETT00000012912; ENSXETP00000012912; ENSXETG00000005867.
DR KEGG; xtr:100486524; -.
DR AGR; Xenbase:XB-GENE-985051; -.
DR Xenbase; XB-GENE-985051; klkb1.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_031604_0_0_1; -.
DR OMA; TTMNYTD; -.
DR TreeFam; TF343687; -.
DR Reactome; R-XTR-140837; Intrinsic Pathway of Fibrin Clot Formation.
DR Reactome; R-XTR-1592389; Activation of Matrix Metalloproteinases.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000005867; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01100; APPLE_Factor_XI_like; 3.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00024; PAN_1; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 4.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..629
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157588"
FT DOMAIN 21..103
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 110..193
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 200..283
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 290..373
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 391..628
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 629 AA; 70403 MW; 6E11952B8912A9A1 CRC64;
MTCYYCLLVF LLFFTLGSGG CISELYQDSY WQGGDLRSVF APDVEYCQLV CTFSPRCLMF
SYLPASWPKE NERFACYLKE SATNMLPKVT LTGAISGHSL KTCKSKINVC RDKNFHGIDM
IGTNYNVTWA TNVQQCKEGC TNDIHCQYFT YVTEQFHSAP MRNRCYFKYS AKGMPTRIRL
LDNVISGFSL KACGKSSLGC QNDLFQNMEL PGETLTRVFA PDVHTCQKIC TFYPNCLFFT
FYKKESKEPL QRNVCYIRTS TKGIPDEGIN KEHTISGFSL LSCKFSPSVC PLTILSDAEF
LGDELLVEEV SGEKECQQEC TNNIRCQFFT YRPMQSGCSE NKCKCHMKIS SNGLPTGIRH
GNGEISGFSL RLCKIKSVKG CGEPIEHANR IVGGTDSVLG EWPWQVSMHL RLTASYKKHA
CGGSIISNQW IVTAAHCFAM HPLPQMWIIY SGVVKLSNIT QSTPFSETEQ IIIHPHYTGA
GNGTDIALLK LKTPISFNDH QKAICLPPRE PTFVLPNSCW ITGWGFTEES GSLANILQKA
EVPQISTEEC QGNYEQTRID KKILCAGYKR GKIDSCKGDS GGPLACVVDE IWYLTGITSW
GEGCARPGKP GVYTRVSEFT DWIIEHTRV
//
