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Database: UniProt
Entry: F6YS11_MONDO
LinkDB: F6YS11_MONDO
Original site: F6YS11_MONDO 
ID   F6YS11_MONDO            Unreviewed;       745 AA.
AC   F6YS11;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   31-JUL-2019, entry version 54.
DE   RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN   Name=CHUK {ECO:0000313|Ensembl:ENSMODP00000013213};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013213, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000013213, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000013213}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   RefSeq; XP_001378103.1; XM_001378066.4.
DR   STRING; 13616.ENSMODP00000013213; -.
DR   Ensembl; ENSMODT00000013455; ENSMODP00000013213; ENSMODG00000010543.
DR   GeneID; 100027952; -.
DR   KEGG; mdo:100027952; -.
DR   CTD; 1147; -.
DR   eggNOG; KOG4250; Eukaryota.
DR   eggNOG; ENOG410XRMU; LUCA.
DR   GeneTree; ENSGT00950000182937; -.
DR   InParanoid; F6YS11; -.
DR   KO; K04467; -.
DR   OrthoDB; 1013139at2759; -.
DR   TreeFam; TF324269; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   Bgee; ENSMODG00000010543; Expressed in 7 organ(s), highest expression level in heart.
DR   GO; GO:0008385; C:IkappaB kinase complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; IEA:Ensembl.
DR   GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0038061; P:NIK/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:1902741; P:positive regulation of interferon-alpha secretion; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR041185; IKBKB_SDD.
DR   InterPro; IPR022007; IKKbetaNEMObind.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF18397; IKBKB_SDD; 1.
DR   Pfam; PF12179; IKKbetaNEMObind; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM01239; IKKbetaNEMObind; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN       15    300       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   COILED      550    570       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   745 AA;  84433 MW;  342F5A17C2D29FCB CRC64;
     MDRPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELGNK IAIKSCRLEL SAKNKDRWCH
     EIQIMKKLNH PSVVKACDVP EEMNFLINDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ
     ILSLLSDIGS GIQYLHENRI IHRDLKPENI VLQDVGGKVI HKIIDLGYAK DLDQGSLCTS
     FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIVGYRP FLHHLQPFTW HEKIKKKDPK
     HIFAFEEMTG EVRFSSHLPQ PNSLSSFIVQ PMEQWLQLML TWDPQQRGGS LDLPHKQPAC
     FGQMEQILNL KIAHILNMTS AKIISFLLFP EESLHSLQSR IEHETGINTA SQELLLEMGI
     SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KIVYEGPFAS RSLSECVNYI VKDSKIQLPV
     MQLRRVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTMI SASQQLKAKL
     QFFHQSIQLD LDRYSDQMTY GISSEKMLKA WKEMEEKAIQ CAQAGDIGYL DEQIMSLHTE
     IVELQRSPSA RRQEDVMESL EQKAIDLYKQ LKPRSPDHSY SDSSEMVKII VLTVQNQDRV
     LKELFGHLSK LLGCKQKIID LLPKIEVALN SIKEADNMVM LMQGKRQREI WHLLKIACTQ
     SSARSLVGTS LEGAATSPPS AGLPSALTAP MPRSLSCVLS AQDGETFTQI VEENLNYLGC
     LSTVIREATE EQGKNLMSLD WSWLK
//
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