ID F6YSS4_XENTR Unreviewed; 1691 AA.
AC F6YSS4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 {ECO:0000313|Ensembl:ENSXETP00000036674};
GN Name=arhgef28 {ECO:0000313|Ensembl:ENSXETP00000036674};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000036674};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000036674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000036674};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000036674}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSXETT00000036674; ENSXETP00000036674; ENSXETG00000016824.
DR AGR; Xenbase:XB-GENE-952324; -.
DR Xenbase; XB-GENE-952324; arhgef28.
DR eggNOG; KOG3520; Eukaryota.
DR HOGENOM; CLU_002466_2_1_1; -.
DR InParanoid; F6YSS4; -.
DR TreeFam; TF334740; -.
DR Reactome; R-XTR-3928662; EPHB-mediated forward signaling.
DR Reactome; R-XTR-8980692; RHOA GTPase cycle.
DR Reactome; R-XTR-9013026; RHOB GTPase cycle.
DR Reactome; R-XTR-9013106; RHOC GTPase cycle.
DR Bgee; ENSXETG00000016824; Expressed in mesonephros and 9 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0060415; P:muscle tissue morphogenesis; IEA:Ensembl.
DR CDD; cd20876; C1_p190RhoGEF; 1.
DR CDD; cd14680; PH_p190RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037819; ARHGEF28_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 662..709
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 859..1054
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1096..1198
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 467..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1451..1531
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 482..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1691 AA; 192142 MW; FA813F625718C6C8 CRC64;
MLGACGFPDK GSFCNLDHHT LDVKMMELSL SEVPLYGQMI VFATFGQDLH LPEDAEFYFV
YNGSSQRHVI FAERLASNVL RSVFPGHNCP ESVIVTVCMH TEGYSPVIVA CTPVTYIRDT
ACNISHYLKM HCGSLSPTSH ETILTHFGLT VKDLLHMDRN MMLCLASEES KPIWNILGSA
SESGSFRGET LLHLTARWGL EEVSHFLMYQ PGGVCGLHTE NEDQETPIDI AARSGHIGLV
ARLRNFQDAP PLDFFTVVIG EDSFLRFCHS TTVLTLTRLQ PQGKSLESDI ELFRKCLWDS
RFIEKITNPM QNQDHKILNQ PDEIHREEDK RYSSIDVLKK LKHPPTFLAA SRLSAMLNGN
DEVYANSMVV DEVTDSEINY IHVDNANTEG SPTHRSDSTL TDKANNYSVC ASPERNRPEV
NNVDQADLPA FLSPSHLYSG AARRQSRTLG YATERNTACN VIKRRSSSLD GLDADSEGEG
TYPRYSSGSS IKQDSPGLLG NSGDELDSPE RNAEPDFPIR GVGTLPLQGK DPLGTGVRLR
SYSCSSPKLS VGIPRIARDL SVSDTSEDGV VSFSGRSLLQ ALSLSKSVYL LHPGKQRAYS
LPDQLREKRI EEEEWDKYAT PTKPESEKNK VSRTFSFLRN RMTSTRNKNK VKNKDMKEKV
NRHQFVTGTF SGVVPCLVCE KALLGKESLQ CSSCNVNVHK GCKESAPHCT KRFQERYHPK
NKQSAVISNS SYKDIPQQVQ PTMHTSTSVP LGLSSGKKET IHSTPLHSKT IPVLSSDRRS
DPSLESDGDT SGCRSRSQSE ELLQTLGTPP SMDCFPIEDV VDTTLWSDFS NDMQEFEAES
WSLVVDPLFC EKQKKDVIKR QDVIFELIQT ELHHVQTLLI MSEIFRKGMK EELQLDHSTV
DKIFPCLDEL LEIHKQFFSN LKERKQESRE GNDKNFIINR IGDILVQQFS ADSANKMKKI
YGEFCSHHIE ALNLFKELQQ NKKFQNFIKL RNRNLLARRR GIPECILLVT QRITKYPVLV
ERILKYTTEG TEEHTDLCKA LVLMKELLAA VDLQVNKFEK GQKLLEILNK IENKTCTKLK
NGLEFRKQDL TSKERALLHE GVVFWKTATG RFKDIQALLL TDILLFLQEK DQKYIFAAVD
QKPPVICLRK LIVREVANEE RGMFLISASS AGPEMYEIHT NSKEERNGWM RQIQEAVQSC
PQEDEGKSCE SDEDKRVAEA RAVKAQKYHD TLTLQDQNIC NTLEEKLQIY AELAALNTKS
DMHLEPHLFI KADSGEIPQA AALLAAALKE AENLHSTIKS QMEDPSWLPE YERSTPRRCR
SVETLDEEPE TSYNSQSPDA RERRKLSYDA SISHVKSDRD LDFTEEIEEC MQSPSYNQDE
VLQVVHNLTR LLYSIQATVA MQDSHIELHK AFLQDYELGS RGSRGSILNE HEKYRNLEKH
RCEMVNLHKL QQQLHQEQQR WLRECDQKQR ENEEKESMLQ HREQECQSQE HLLHQKREEL
DQQQQEFQQN VERLQEGHRL VEREKEDLAV KLKLWRHFNN HQPRSLLTEG VGSRRSVSLQ
DEDSVYINSA LAQISLNTIT TFPAPDYPNA HLFHSPSSLL AQSTEKNTTD TANEPWSSVV
SRHQRLEGSS LISRHNKDAC NNDLNAAHVI SCGTLLSVPN ATQPVEPQTK PAEETSHHLE
NGKIEENIVY L
//
