ID F6YTL9_HORSE Unreviewed; 1879 AA.
AC F6YTL9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Plexin D1 {ECO:0000313|Ensembl:ENSECAP00000007794.3};
GN Name=PLXND1 {ECO:0000313|Ensembl:ENSECAP00000007794.3,
GN ECO:0000313|VGNC:VGNC:21607};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007794.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007794.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007794.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007794.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007794.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSECAT00000010133.4; ENSECAP00000007794.3; ENSECAG00000009159.4.
DR VGNC; VGNC:21607; PLXND1.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR OrthoDB; 1387371at2759; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000009159; Expressed in synovial membrane of synovial joint and 21 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR CDD; cd11247; Sema_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR042719; Plexin-D1_Sema.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1226..1248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..423
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1879 AA; 207205 MW; 1218DA181C6B9121 CRC64;
MARRAAGGAP LSARAAAASP PPPPPRPPFW APPGPRGPPP RPPLLLPLLL LLGTARAGAL
EIQRRFPSPT PTNNFALDGA AGTVYLAAVN RLYQLSGANL SLEAEAAVGP VADSPLCHAP
QLPQASCEHP RRLTDNYNKI LQLDPGQGLV VVCGSIYQGF CQLRRRGNIS AVAVRFPPAA
PPAEPVTVFP SMLNVAANHP NASTVGLVLP PAAGTGGSRL LVGATYTGYG SAFFPRNRSL
EDHRFENTPE IAIRSLDARG DLAKLFTFDL NPSDDNILKI KQGAKEQHKL GFVRAFLHPP
DPPPGAPSYA YLALNSEARA GDKESQAQSL LARICLPRGA GGDAKKLTES YIQLGLQCAG
GAGRGDLYSR LVSVFPASEL LFAVFERPQG PPAARAAPAA LCAFRFADVQ AAIRAARTAC
FEEPAPDVVA VLDSVVQGTG PACERKRNIQ INLNESMQVV SRRVVTVAYG EPVHHVMQFD
PADPGYLYLM TSHQMARVKV AACAMHTTCR DCVGAADAYC GWCALETRCT LQQDCANSSQ
WHFWTSASKG PGGCPAMTVL PAEIDVRQEY PGMILQISGS LPSLSGMDMV CDYGNNIRTV
ARVPGPAFGH QIAYCNLLPR DQFPPFPPHQ DHVTIEMSVR VNGRNIVQAN FTIYDCSRIG
QVYPHTACTS CLSAQWPCFW CTQQHTCVSN QSRCEASPNP TSPQDCPRIL PSALAPVPTG
GSQSIPVHLA NAAFFQGAAL ECSFGPEEIF EAVWVNESAV RCNQVVLHTT QKSQVFPLSL
QVKGRPARFL DSPDPMTVEV YNCAMGSPDC SQCLGREDLG HLCVWSDSCR LRGPLQSLPG
TCPAPEIRAI EPLSGPLDGG TLLTIRGRNL GRRLSDVAHG VWIGSVACEP LADRYTVSEE
IVCATGPAPE AFSDVVTVNT SKEGKSRERF SYVLSLVHSL EPAMGPKAGG TRITIHGSDL
HVGSELQVLV NDTEPCTELV RRDTSITCMV PGAALPAPVP VCVRLERRGC LRGNLTFWYM
QNPVITAISP RRSPVSGGRT ITVAGERFHM VQNVSMAVHH IGREPTLCKV LNSTLITCPS
PGALSNASAP VDFFINGRAY ADEVAVAEEL LDPEEAQRGS PFRLDYLPDP QFSTAKREKW
IKHHPGEPLT LVIHKEQDSL GLERHEYRVK IGQVACDIQI VSDRVIHCSV NESLGTAEGQ
LPITIQVGNF NQTIATLQLG GSETAIVVSI VICSVLLLLS VVALFVFCTK SRRAERYWQK
TLLQMEEMES QIREEIRKGF AELQTDMTDL TKELNRSQGI PFLEYKHFVT RTFFPKCSSL
YEERYVLPSQ TLNSQGSSPV QETHPLLGEW KIPESCRPNM EEGISLFSSL LNNKHFLIVF
VHALEQQKDF AVRDRCSLAS LLTIALHGKL EYYTGIMKEL LVDLIDASAA KNPKLMLRRT
ESVVEKMLTN WMSICMYSCL RETVGEPFFL LLCAIKQQIN KGSIDAITGK ARYTLNEEWL
LRENIEAKPR NLNVSFQGCG MDSLSVRAMD TDTLTQVKEK ILEAFCKNVP YSQWPRAEDV
DLEWFASSTQ SYILRDLDDT SVVEDGRKKL NTLAHYKIPE GASLAMSLTD KKDNTLGRVK
DLDTEKYFHL VLPTDELAEP KKSHRQSHRK KVLPEIYLTR LLSTKGTLQK FLDDLFKAIL
SIREDKPPLA VKYFFDFLEE QAEKRGISDP DTLHIWKTNS LPLRFWVNIL KNPQFVFDID
KTDHIDACLS VIAQAFIDAC SISDLQLGKD SPTNKLLYAK EIPEYRKIVQ RYYKQIHDMT
PLSEQEMNAH LAEESRKYQN EFNTNVAMAE IYKYAKRYRP QIMTALEANP TARRSQLQHK
FEQVVALMED NIYECYSEA
//
