ID   F6YTY3_CIOIN            Unreviewed;      1153 AA.
AC   F6YTY3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Exportin-6 {ECO:0000313|Ensembl:ENSCINP00000014157.3};
GN   Name=LOC100187212 {ECO:0000313|Ensembl:ENSCINP00000014157.3};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000014157.3, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA   Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA   Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA   Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA   Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA   Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA   Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA   Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA   Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA   Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA   Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA   Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA   Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000014157.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   EMBL; EAAA01002908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6YTY3; -.
DR   STRING; 7719.ENSCINP00000014157; -.
DR   Ensembl; ENSCINT00000014157.3; ENSCINP00000014157.3; ENSCING00000006884.3.
DR   GeneTree; ENSGT00390000002810; -.
DR   InParanoid; F6YTY3; -.
DR   OMA; KITRFNH; -.
DR   TreeFam; TF323443; -.
DR   Proteomes; UP000008144; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040016; XPO6.
DR   PANTHER; PTHR21452; EXPORTIN-6; 1.
DR   PANTHER; PTHR21452:SF4; EXPORTIN-6; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          31..97
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1153 AA;  131617 MW;  88B444C8FE702F55 CRC64;
     MANLEEISVG LERLMTEFFH ISTGNKRKRE IEEQLNKFGN QNGSWKHCLE IFTKTGNEYV
     MMYCLSVLEN LVNKMWLGCD PNTKGEIRRS LNHILLVQHK KVPMFITNKL VKVIVDIGRS
     DWPMFYPDFF SGLLQLASSS GGSNTRALGL IALRIASEEL ASPREDVSGQ RKEELRKLLL
     QQVPDMIAII TESLRIEWEA NFRQFSHVNK ATPPPSPGSG ESNLFDLFVF QGDSLPHITT
     VNIPPHSLSI MTHALECLCQ LFSWIPLSTS ITPDLLSVVF RYARLGTSDS LQNSSSFTST
     DIFITNYIHS YIVKILFIPS GLTLSELGCK AMMCVNELMS KNCVPHNFEE YLVRIFRQTF
     HLLQQLTRGD NPRESLDKLD DNYLEKFIEF LRLFVSLHFS RIASNQSFPL LQFLTLLFKF
     TFHQTSHEHY INCLDIWEIF VDYVTNTAEK SKEDKEYVLT RYREGMVLFS TSILQHIQFR
     FNANHLTELD DGTMDDNGHT EWEMYLIENI ELIAKIGKLF PNETISLLTT FVNLKEFLDK
     TLNIQIIFLI ETNWSMVSTL DVNQLPRLQR SMRDLAMCLQ AFGRISELFL AENFQEHFQT
     ALTLIQKFLT IALFGCKNHL YQSSNLPPAV VKDATAVQAE ALACLQPYTH WLSQLYSEAQ
     HAGHSQAQLS QLLSSYMDVI VPVLSKQVPD KISLSSAHTL LSVVTTVRAT FLSQSPAIQK
     LYHDVANGLC NKLPMKTQSL IYRSLSSLLL FPWPNTPEAE QSWHERSENH KTFIKSLLGE
     YMSLSNNLSA LQTDHNLYER AKPVILRAVL ILDGVVEAVA DEASKSRQLC HSSIEQCITI
     SLQLFPIYIS HPDTVEVLMS LFLRIFSALR RQIGPDSIAR TLQSFLTTFT PERLQETILH
     ENAAGVRVVE KFIEILELVI DETGNAFKTF TPSIIVFAVQ QIYPIVSQRE SSDVKGPLFH
     LLSHVLSRRH RYFFPSPVLA SMLQDGSVNS SKSGTIAHKQ QFLAIMTAFG QSFLQSDINI
     FKQVLDTLED LNSKQKLYEK LYFMLSEEGV LFQFVNVLIQ ALLNKTHNLL QEEICTAVFN
     MSSVDLDYFH SNFLQQFLQH AEGVTADQKH SLYSAFKPER DAPSFTSRLL LFVNDLRFFK
     LSNSSLPEGT VQF
//