ID F6YUY3_MACMU Unreviewed; 1284 AA.
AC F6YUY3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 {ECO:0000313|Ensembl:ENSMMUP00000000427.4};
GN Name=RAPH1 {ECO:0000313|Ensembl:ENSMMUP00000000427.4,
GN ECO:0000313|VGNC:VGNC:99397};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000000427.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000000427.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000000427.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMMUT00000000460.4; ENSMMUP00000000427.4; ENSMMUG00000000314.4.
DR VEuPathDB; HostDB:ENSMMUG00000000314; -.
DR VGNC; VGNC:99397; RAPH1.
DR GeneTree; ENSGT00940000156552; -.
DR Proteomes; UP000006718; Chromosome 12.
DR Bgee; ENSMMUG00000000314; Expressed in liver and 22 other cell types or tissues.
DR ExpressionAtlas; F6YUY3; baseline.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16136; RA_MRL_Lpd; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 301..387
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 428..537
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..685
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..757
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..818
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..890
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..924
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..983
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1060
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 139095 MW; E5E6E24265C604A0 CRC64;
MSVFQMEQLS DEEIDHGAEE DSDKEDQDLD KMFGAWLGEL DKLTQSLDSD KPMEPVKRSP
LRQETNMANF SYRFSIYNLN EALNQGETVD LDALMADLCS IEQELSSIGS GNSKRQITET
KATQKLPVSR HTSKPGTLKG LSSSSNRIAK PSHASYSLDD VTAQLEQASL SMDEAAQQSV
LEDTKPLVTN QHRRTASAGT VSDAEVRSIS NSSRSSITSA ASSMDSLDID KVTRPQELDL
THQGQPIPEH AISLRCSSKQ AKHHIDFTEE QAELTPEEQA AKLKAEKIRV ALEKIKEAQV
KKLVIRVHMS DDSSKTMMVD ERQTVRQVLD NLMDKSHCGY SLDWSLVETV SELQMERIFE
DHENLVENLL NWTRDSQNKL IFMERIEKYA LFKNPQNYLL GKKETAEMAD RNKEVLLEEC
FCGSSVTVPE IEGVLWLKDD GKKSWKKRYF LLRASGIYYV PKGKAKVSRD LVCFLQLDHV
NVYYGQDYRN KYKAPTDYCL VLKHPQIQKK SQYIKYLCCD DVRTLHQWVN GIRIAKYGKQ
LYMNYQEALK RTESTCDWTS LSSSSIKSGS SSSSIPESQS NHSNQSDSGV SDTQPAGHVR
SQSIVSSIFS EAWKRGTQLE ESSKARMESM NRPYTSLVPP LSPQPKIVTP YTASQPSPPL
PPPPPPPPPP PPPPPPPPPP LPSQSAPSAG SAAPMFVKYS TITRLQNASQ HSGALFKLPT
PPVMQPQSVK PQILVPPNGV VPPPPPPPPP PTPGSAMAQL KPAPCTPSLP QFSAPPPPLK
IHQVQHITQV APPAPPPPPP IPAPLPPQAP PKPLVTIPPP TSTKTVAPVV TQAAPPTPTP
PVPPAKKQPA FPVSYIPPSP PTPPVPVPPP TLPKQQSFCA KPPPSPLSPV PSVVKQIASQ
FPPPPTPPAM ESQPLKPVPA NVAPQSPPAV KAKPKWQPSS IPVPSPDFPP PPPESSLVFP
PPPPSPVPAP PPPPPPPTAS PTPDKSGSPG KKTSKTSSPG GKKPPPTPQR NSSIKSSSGA
EHPEPKRPSV DSLVSKFTPP AESGSPSKET LPPPAAPPKP GKLNLSGVNL PGVLQQGCVS
AKAPVLSGRG KDSMVEFPSP PSDSDFPPPP PETELPLPPI EIPAVFSGNA SPKVAVVNPQ
PQPWSKMSVK KAPPPTRPKR NDSTRLTQAE ISEQPTMATV VPQVPTSPKS SLSVQPGFLA
DLNRTLQRKS ITRHGSLSSS RMSRAEPTAT MDDMALPPPP PELLSDQQKA GYGGSHISGY
ATLRRGPPPA PPKRDQNTKL SRDW
//
