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Database: UniProt
Entry: F6YVE1_HORSE
LinkDB: F6YVE1_HORSE
Original site: F6YVE1_HORSE 
ID   F6YVE1_HORSE            Unreviewed;      1452 AA.
AC   F6YVE1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   28-MAR-2018, entry version 31.
DE   SubName: Full=Kielin/chordin-like protein {ECO:0000313|Ensembl:ENSECAP00000021970};
GN   Name=KCP {ECO:0000313|Ensembl:ENSECAP00000021970};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021970, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000021970, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021970,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000021970}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021970};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   STRING; 9796.ENSECAP00000021970; -.
DR   PaxDb; F6YVE1; -.
DR   Ensembl; ENSECAT00000026345; ENSECAP00000021970; ENSECAG00000024406.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; ENOG410XQ7V; LUCA.
DR   GeneTree; ENSGT00840000129763; -.
DR   InParanoid; F6YVE1; -.
DR   OMA; EAYASHC; -.
DR   OrthoDB; EOG091G0O1O; -.
DR   TreeFam; TF106451; -.
DR   Proteomes; UP000002281; Chromosome 4.
DR   Bgee; ENSECAG00000024406; -.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF00093; VWC; 9.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00214; VWC; 19.
DR   SMART; SM00215; VWC_out; 10.
DR   SMART; SM00216; VWD; 1.
DR   PROSITE; PS01208; VWFC_1; 7.
DR   PROSITE; PS50184; VWFC_2; 14.
DR   PROSITE; PS51233; VWFD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28   1452       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003346362.
FT   DOMAIN      137    190       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      251    310       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      310    368       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      424    483       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      483    542       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      542    600       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      600    658       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      720    777       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      777    836       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      895    954       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      954   1012       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1012   1080       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1077   1140       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1144   1204       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     1209   1423       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   COILED       66     93       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1452 AA;  155558 MW;  E2EF843D61E4AD26 CRC64;
     MAGPPAALLP LVLQLTSLAL APGAGRAMPR EHRGLADIDD YQQQAPAHSA PAGAPQEQWR
     PLEARLGRLE AEVTELRKQN KELQVKVRQL ESSAPQCWGL GRAWPQGARW EPDACTTCIC
     QDGAVRCDPK PGLPHCHGCS HDGQAYGNGE TFFPDACTTC CCREGTITCT QKPCPRGPCL
     EPGACCPHCE PRCEYEQLYE EGANFLSSSN PCLQCSCLRS LVRCVLMKCP PSPCLEPVLR
     PGHCCPTCQE ACCTEGGSHW EHGREWTAPG DPCQICQCLE GHIQCRQREC TSLCPYPARP
     LPGTCCPVCD GCFLNGREYR SGEPVGSGDP CLHCRCANGS VQCEPLPCPP AHCRHPGRIP
     GQCCPVCDGC EYQGHQYQSG ETFRLRESGR CIRCSCQAGE VSCEEQECPV APCTLSDSGP
     QLCPACVLDG EEFAEGVQWE PDGQPCTACS CQEGVPMCGA VLCSPAPCQH PTQHPGACCP
     SCESCTYHGQ VYANGQNFTD ADSPCHSCRC EDGTVRCALV DCPPTTCARP QSGPGQCCPR
     CPDCILEEQV FVDGESFSHP RDPCQECRCQ EGHAHCQPRA CPRAPCAHPL PGPCCQSDCN
     GCAFGGKEYP NGADFPHPSD PCRLCRCLSG NVQCLARRCP PLPCPEPVLR PGCCPQCPAA
     PSGCPRPGGA GPASHQEHFS SLGDPCRRCL CLHGSVSCQR LCPPAPCAHS RQGPCCPSCD
     GCLYQGKEFA SGERFPSPTA ACHVCLCWEG SVSCEPRACA PAQCPFPARG DCCPACDGCE
     YLGESYLSSQ DFPDPREPCN LCTCLGGFVT CGRRPCEPLG CSHPLTPPGH CCPTCQGCLY
     HGVKAAPGET LPDPLDPTCS HCTCQEGSMR CQKKPCPPAL CPNPSPGPCF CPVCHSCVSQ
     GRERQDGEEF EGPPGSCERC RCQAGQVSCV RLQCPPLSCP LQVTAQGSCC PRCRGCLAHG
     EEHPEGSRWE PPDSPCSSCV CHEGVVTCAH VQCVSSCAQP HQGPGDCCPR CSDCEHEGRK
     YEPGESFQPG ADPCEVCICE LEPEGRPSLR CHRRQCPSLV GCPASQLLPP GPQHCCPTCT
     QALSNCTEGL LGSELVPPDP CYTCQCQDLT WLCIHRACPE LSCPPSEHHM PPESCCPVCR
     APAQSCAHQG REVASGERWA VDACTSCSCV AGTVICQSRL CPLLSCGPDE APALSPGSCC
     PRCLLRPASC MAFGDPHYRT FDGRLLHFQG SCSYVLAKDC RGGDFSVHVT NDDRGRGGVA
     WTQEVTVLLE DVAVRLLQGG AVMVDGRRVA LPFLKEPLLY AELRGRTVIL HGWPGLQVLW
     DGQSQVEVRV PGSYRGQICG LCGNFNGFAQ DDLQGPEGLL LSTEAAFGNS WQVQEGRACP
     SGLELPTMLL EMERSRWAQE QLLWDLELLT GAGLGLFWPP WAQFCGPRDQ ASCAWSQCSK
     PCGRTGGGSE RL
//
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