ID F6YW83_MONDO Unreviewed; 2433 AA.
AC F6YW83;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Ubiquitin specific peptidase 24 {ECO:0000313|Ensembl:ENSMODP00000004672.4};
GN Name=USP24 {ECO:0000313|Ensembl:ENSMODP00000004672.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004672.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000004672.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000004672.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 13616.ENSMODP00000004672; -.
DR MEROPS; C19.047; -.
DR Ensembl; ENSMODT00000004772.4; ENSMODP00000004672.4; ENSMODG00000003814.4.
DR eggNOG; KOG1866; Eukaryota.
DR GeneTree; ENSGT00940000159474; -.
DR HOGENOM; CLU_000331_1_0_1; -.
DR InParanoid; F6YW83; -.
DR OMA; CSCYMNS; -.
DR TreeFam; TF323966; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000003814; Expressed in adult mammalian kidney and 18 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR CDD; cd17065; Ubl_UBP24; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR047061; UBP24_Ubl.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF729; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 24; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 1502..1855
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 847..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1876..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2388..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2388..2420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2433 AA; 274747 MW; 3755447ED3344A90 CRC64;
LLTSSAVHKW GTEIHEGIYN MLMLLVDLAA ERVKQDPIPI GLLGVLTMAF NPDNEYHFKN
RMKVSQRNWA EIFGEGNMFA ISPVSAFQKE PHGWLVDLVN RFGELGGFAA IQSKLHSEDI
ELGAVSALVQ PLGVCAEYLN SSVVQPMLDP VIHKMIKYVQ SVEEKDLKDK RLVSIPELLS
AIKLLCMRFQ PDLVMVVDDL RLDILLRMLK SPHFSAKMNS LKEVTKLIED STLSKSVKNA
IDTDRLLDWL VENSVLSIAL EGNIDQAQYC DRIKGIIELL GSKLSLDELT KIWRIQAGQS
STVIENIHTI IAAAAVKFSS DQLNHLFVLI QKSWETENDR VRQKLLSLIG RIGREARFET
TSGKVLEVLW DLAHLPTLPS SLIQQALEEH LTILSDAYAV KEAIKRSYII KCIEDIKRPG
EWSGLEKNKK DGFKSSQHNN PQFVWVVPAL RQLHEITRSF IKQTYQKQDK SIIQDLKKNF
EIVKLVTGSL IACHRLAASV SAPGGLTGST LVDGRYTYRE YLEAHLKFLA FFLQEATLYL
GWNRAKEIWE CLVTGQDVCE LDREMCFEWF TKGQHDLESD VQQQLFKEKI LKLESYEITM
NGFGLFKTFF ENVNLCDHRL KRQGTQLYVE KLELIGMDFI WKIAMESPDE EIANEAIQLI
ISYSYINLNP RLKKDSVSLH RKFIADCYAR LEAASSALGG PTLTHAVTRA TKMLTATAMP
TVATSVQSPY RSTKLVIIER LLLLAERYVI TIEDLYSVPR TILPHGASFH GHILTLSVTC
ESTKDTFTVE AHSNETIGSV RWKIAKQLNS PVDNIQIFAN DSLLTVNKDQ KLLHQLGFSE
EQALTVKTSG SGTPSGGSAD SSASSSSSSG VFSSSYVMEQ EKSLPGVVMA LVCNVFDMLY
QLANLEEPRI TLRVRKLLLL IPTDPAIQEA LDQLDSLGRK KTLLSETSSQ SSKSPSLSSK
QQHQPSASSI LESLFRSFAP GMSTFRVLYN LEVLSSKLMP TADDEMARNC AKSFCENFLR
AGGLSLVVNV MQRDSIPSEV DYETRQGVYS ICLQLARFLL VGQTMPTFLD EDLTKDGIEA
LTSRPFRNIS RQSSRQMSLC GTPEKASYRQ LSVSDRSSIR VEEIIPAARV AIQTMDVNDF
TSTVACFMRL SWAAAAGRLD LVGSSQPIKE SNTLFPIGIR NRLSSSGSNC SSGSEGEPVA
LHAGICVRQQ SVSTKDALIA GEALSLLVTC LQLRSQQLAS FYNLPCVADF IIDILLGSPS
AEIRHVACDQ LYTLSQTDTS AHPDVQKPNQ FLLSVILTAQ LPLWSPTSIM RGVNQRLLSQ
CMEYFDLRCQ LLDDLTTSEM DQLKISPATM LEDEITWLDN FEPNRTAECE TSEADNILLA
GHLRLIKTLL SLCGAEKEML GSSLIKPLLD DFLFRASRII LNSHSPAGSA AISQQDFHPK
CSTVNSRLAA YEVLVMLADS SPSNLQIITK ELLSMHHQPD PALTKEFDYL PPVDSRSLSG
FVGLKNGGAT CYMNAVFQQL YMQPGLPESL LSVDDDMDNP DDSVFYQVQS LFGHLMESKL
QYYVPENFWK IFKMWNKELY VREQQDAYEF FTSLIDQMDE YLKKIGRDQI FKNTFQGIYS
DQKICKDCPH RYEREEAFMA LNLGVTSCQS LEISLDQFVR GEVLEGSNAY YCEKCKEKRT
TVKRTCIKSL PSVLVIHLMR FGFDWESGRS IKYDEQIRFP WMLNMEPYTV SGMARQDSSC
DVGENGRHVD AGSGGSPRKK VAPTENYELV GVIVHSGQAH AGHYYSFIKD RRGCGKGKWY
KFNDTVVEEF ELNDETLEYE CFGGEYRPKV YDQSNPYPDV RRRYWNAYML FYQRVSDQNS
PVLPKKSRVS VVRQEAEDLS LSAPSSPEIS PQSSPRPHRP NNDRLSILTK LVRKGEKKGL
FVEKMPVRIY QMVRDENLKF MKNRDVYSSD YFSFVLSLAS LNATKLKHPH YPCMAKVSLQ
LAVQFLFQTY LRTKKKLRVD TEEWVATIEA LLSKSFDACQ WLVEYFVSSE GRELVKIFLL
ECSVREVRVA VATILEKTLD SALFYQDKLK SLHQLLEVLL ALLDKDVPEN CKNCAQYFFL
FNTFVQKQGI RASDLLLRHS ALRHMINFLL GPNRQNNQIR RWSSAQAREF GFLHNTVALL
VLHSDVSSQR NVAPGIYKQR PPISIVSSSP LLALHEEVES LLFLSEGKPY LLEVMFALRE
LTGSLLALME MVVYCCFCNE HFSFTMLHFI KNQLETAPPH ELKNTFQLLH EILVIEDPLQ
VERVKFAFET ESGLVALMHH SNHVDSSRCY QCVKFLVTLA QKCPAAKEYF KENSHHWSWA
VQWLQKKMSE HYWVPQSNIS NETSTGKTFQ RTISAQDTLA YATALLNEKD QSGSSNGSES
SPANENGERH LQQGSESPMM IGESRSDLDD VDP
//
