ID F6YW98_HORSE Unreviewed; 1355 AA.
AC F6YW98;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Adhesion G protein-coupled receptor L1 {ECO:0000313|Ensembl:ENSECAP00000019647.2};
GN Name=ADGRL1 {ECO:0000313|Ensembl:ENSECAP00000019647.2,
GN ECO:0000313|VGNC:VGNC:58115};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019647.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000019647.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019647.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000019647.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019647.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSECAT00000023703.3; ENSECAP00000019647.2; ENSECAG00000021555.3.
DR VGNC; VGNC:58115; ADGRL1.
DR GeneTree; ENSGT00940000159684; -.
DR HOGENOM; CLU_002753_1_1_1; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000021555; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR ExpressionAtlas; F6YW98; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd16007; 7tmB2_Latrophilin-1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR031234; Latrophilin-1_TM.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF62; ADHESION G PROTEIN-COUPLED RECEPTOR L1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 739..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 885..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..280
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 359..418
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 741..982
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 282..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1196
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 22..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1355 AA; 149027 MW; 974449C3D0362256 CRC64;
MAKGQGAESL EPQSASSCIF VCPGTLQKVL EPTSTHESEH QSGAWCKDPL QAGDRIYVMP
WIPYRTDTLT EYASWEDYVA ARHTTTYRLP NRVDGTGFVV YDGAVFYNKE RTRNIVKYDL
RTRIKSGETV INTANYHDTS PYRWGGKTDI DLAVDENGLW VIYATEGNNG RLVVSQLNPY
TLRFEGTWET GYDKRSASNA FMVCGVLYVL RSVYVDDDSE AAGNRVDYAF NTNANREEPV
SLAFPNPYQF VSSVDYNPRD NQLYVWNNYF VVRYSLEFGP PDPSAGPATS PPLSTTTTAR
PTPLTSTVSP AATTPLRRAP LTTHPVGAIN QLGPDLPPAT APAPSTRRPP APNLHVSPEL
FCEPREVRRV QWPATQQGML VERPCPKGTR GIASFQCLPA LGLWNPRGPD LSNCTSPWVN
QVAQKIKSGE NAANIASELA RHTRGSIYAG DVSSSVKLME QLLDILDAQL QALRPIERES
AGKNYNKMHK RERTCKDYIK AVVETVDNLL RPEALESWKD MNATEQVHTA TMLLDVLEEG
AFLLADNVRE PARFLAAKQN VVLEVTVLNT EGQVQELVFP QEYPSENSIQ LSANTIKQNS
RNGVVKVVFI LYNNLGLFLS TENATVKLAG DAGAGSPGGA SLVVNSQVIA ASINKESSRV
FLMDPVIFTV AHLEAKNHFN ANCSFWNYSE RSMLGYWSTQ GCRLVESNKT HTTCACSHLT
NFAVLMAHRE IYQGRINELL LSVITWVGIV ISLVCLAICI STFCFLRGLQ TDRNTIHKNL
CINLFLAELL FLVGIDKTQY EVACPIFAGL LHYFFLAAFS WLCLEGVHLY LLLVEVFESE
YSRTKYYYLG GYCFPALVVG IAAAIDYRSY GTEKACWLRV DNYFIWSFIG PVSFVIVVNL
VFLMVTLHKM IRSSSVLKPD SSRLDNIKSW ALGAIALLFL LGLTWAFGLL FINKESVVMA
YLFTTFNAFQ GVFIFVFHCA LQKKVHKEYS KCLRHSYCCI RSPPGGAHGS LKTSAMRSNT
RYYTGTQSRI RRMWNDTVRK QTESSFMAGD INSTPTLNRG TMGNHLLTNP VLQPRGGTSP
YNTLIAESVG FNPSSPPVFN SPGSYREPKH PLGGREACGM DTLPLNGNFN NSYSLRSGDF
PPGDGAPEPP RGRNLADAAA FEKMIISELV HNNLRGSGSG AKGPPPPEPP VPPAPGGSGE
EEAGGPGGAD RAEIELLYKA LEEPLLLPRA QSVLYQSDLD ESESCTAEDG ATSRPLSSPP
GRDSLYASGA NLRDSPTYPD SSPEGPSEAL PPPPPAPPGP PEIYYTSRPP ALVARNPLQG
YYQVRRPSHE GYLAPPGLEG PGPDGDGQMQ LVTSL
//