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Database: UniProt
Entry: F6YW98_HORSE
LinkDB: F6YW98_HORSE
Original site: F6YW98_HORSE 
ID   F6YW98_HORSE            Unreviewed;      1355 AA.
AC   F6YW98;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Adhesion G protein-coupled receptor L1 {ECO:0000313|Ensembl:ENSECAP00000019647.2};
GN   Name=ADGRL1 {ECO:0000313|Ensembl:ENSECAP00000019647.2,
GN   ECO:0000313|VGNC:VGNC:58115};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000019647.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000019647.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019647.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000019647.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000019647.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   Ensembl; ENSECAT00000023703.3; ENSECAP00000019647.2; ENSECAG00000021555.3.
DR   VGNC; VGNC:58115; ADGRL1.
DR   GeneTree; ENSGT00940000159684; -.
DR   HOGENOM; CLU_002753_1_1_1; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000021555; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR   ExpressionAtlas; F6YW98; baseline.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   CDD; cd16007; 7tmB2_Latrophilin-1; 1.
DR   Gene3D; 1.25.40.610; -; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR003924; GPCR_2_latrophilin.
DR   InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR031234; Latrophilin-1_TM.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   PANTHER; PTHR12011:SF62; ADHESION G PROTEIN-COUPLED RECEPTOR L1; 1.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF02354; Latrophilin; 1.
DR   Pfam; PF02191; OLF; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PRINTS; PR01444; LATROPHILIN.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00284; OLF; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        739..766
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        778..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        810..834
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        846..865
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        885..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        929..952
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        958..981
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..280
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51132"
FT   DOMAIN          359..418
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          741..982
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          282..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1129..1153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1173..1209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1241..1310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1328..1355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1182..1196
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1241..1259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1285..1305
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        22..204
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   1355 AA;  149027 MW;  974449C3D0362256 CRC64;
     MAKGQGAESL EPQSASSCIF VCPGTLQKVL EPTSTHESEH QSGAWCKDPL QAGDRIYVMP
     WIPYRTDTLT EYASWEDYVA ARHTTTYRLP NRVDGTGFVV YDGAVFYNKE RTRNIVKYDL
     RTRIKSGETV INTANYHDTS PYRWGGKTDI DLAVDENGLW VIYATEGNNG RLVVSQLNPY
     TLRFEGTWET GYDKRSASNA FMVCGVLYVL RSVYVDDDSE AAGNRVDYAF NTNANREEPV
     SLAFPNPYQF VSSVDYNPRD NQLYVWNNYF VVRYSLEFGP PDPSAGPATS PPLSTTTTAR
     PTPLTSTVSP AATTPLRRAP LTTHPVGAIN QLGPDLPPAT APAPSTRRPP APNLHVSPEL
     FCEPREVRRV QWPATQQGML VERPCPKGTR GIASFQCLPA LGLWNPRGPD LSNCTSPWVN
     QVAQKIKSGE NAANIASELA RHTRGSIYAG DVSSSVKLME QLLDILDAQL QALRPIERES
     AGKNYNKMHK RERTCKDYIK AVVETVDNLL RPEALESWKD MNATEQVHTA TMLLDVLEEG
     AFLLADNVRE PARFLAAKQN VVLEVTVLNT EGQVQELVFP QEYPSENSIQ LSANTIKQNS
     RNGVVKVVFI LYNNLGLFLS TENATVKLAG DAGAGSPGGA SLVVNSQVIA ASINKESSRV
     FLMDPVIFTV AHLEAKNHFN ANCSFWNYSE RSMLGYWSTQ GCRLVESNKT HTTCACSHLT
     NFAVLMAHRE IYQGRINELL LSVITWVGIV ISLVCLAICI STFCFLRGLQ TDRNTIHKNL
     CINLFLAELL FLVGIDKTQY EVACPIFAGL LHYFFLAAFS WLCLEGVHLY LLLVEVFESE
     YSRTKYYYLG GYCFPALVVG IAAAIDYRSY GTEKACWLRV DNYFIWSFIG PVSFVIVVNL
     VFLMVTLHKM IRSSSVLKPD SSRLDNIKSW ALGAIALLFL LGLTWAFGLL FINKESVVMA
     YLFTTFNAFQ GVFIFVFHCA LQKKVHKEYS KCLRHSYCCI RSPPGGAHGS LKTSAMRSNT
     RYYTGTQSRI RRMWNDTVRK QTESSFMAGD INSTPTLNRG TMGNHLLTNP VLQPRGGTSP
     YNTLIAESVG FNPSSPPVFN SPGSYREPKH PLGGREACGM DTLPLNGNFN NSYSLRSGDF
     PPGDGAPEPP RGRNLADAAA FEKMIISELV HNNLRGSGSG AKGPPPPEPP VPPAPGGSGE
     EEAGGPGGAD RAEIELLYKA LEEPLLLPRA QSVLYQSDLD ESESCTAEDG ATSRPLSSPP
     GRDSLYASGA NLRDSPTYPD SSPEGPSEAL PPPPPAPPGP PEIYYTSRPP ALVARNPLQG
     YYQVRRPSHE GYLAPPGLEG PGPDGDGQMQ LVTSL
//
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