ID F6YWM3_HORSE Unreviewed; 364 AA.
AC F6YWM3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Growth differentiation factor 3 {ECO:0000313|Ensembl:ENSECAP00000014595.1};
GN Name=GDF3 {ECO:0000313|Ensembl:ENSECAP00000014595.1,
GN ECO:0000313|VGNC:VGNC:18290};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014595.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000014595.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014595.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000014595.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014595.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_001493186.1; XM_001493136.1.
DR AlphaFoldDB; F6YWM3; -.
DR SMR; F6YWM3; -.
DR STRING; 9796.ENSECAP00000014595; -.
DR PaxDb; 9796-ENSECAP00000014595; -.
DR Ensembl; ENSECAT00000017924.3; ENSECAP00000014595.1; ENSECAG00000017031.3.
DR GeneID; 100061071; -.
DR KEGG; ecb:100061071; -.
DR CTD; 9573; -.
DR VGNC; VGNC:18290; GDF3.
DR GeneTree; ENSGT00940000162534; -.
DR HOGENOM; CLU_020515_4_0_1; -.
DR InParanoid; F6YWM3; -.
DR OMA; LDVAKDW; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF351789; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000017031; Expressed in inner cell mass and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0048859; P:formation of anatomical boundary; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045605; P:negative regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR GO; GO:0010453; P:regulation of cell fate commitment; IEA:Ensembl.
DR GO; GO:0002021; P:response to dietary excess; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Ensembl.
DR CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF38; GROWTH_DIFFERENTIATION FACTOR 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..364
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003351701"
FT DOMAIN 247..364
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 364 AA; 40770 MW; B81F9D134C288C48 CRC64;
MIPSLPALAL GLLLTLALGQ TFQFQENVFL QFLGLDKVPS PQKFQPVPYI LKKIFQDREA
AATTGGSQDL CSIKNLGVRG NVLRLLPDQG FYLYSKDLPQ ASCLQKLLYF NLAAIRDKEQ
LTMAQLGLDL GSNTYYNLGP ELELALSLVQ EPRVWGQSIS TPGKPFALQS VPWPQGVLRF
NLLDVAKDWN NNPQKNLGLF LEILVKGDRD FGVNFQLEDT CARLRHSLHA SLLVVTLNPE
QCHPSSRKRR SAIPAPNASC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGDCPFS
LTTSLNSSNY AFMQALMHAV DPQIPQAVCI PTKLSPISML YQDNDDNVIL RHYEDMVVDE
CGCG
//
