GenomeNet

Database: UniProt
Entry: F6YWV8_HORSE
LinkDB: F6YWV8_HORSE
Original site: F6YWV8_HORSE 
ID   F6YWV8_HORSE            Unreviewed;       342 AA.
AC   F6YWV8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Transmembrane p24 trafficking protein 4 {ECO:0000313|Ensembl:ENSECAP00000014584.2};
GN   Name=TMED4 {ECO:0000313|Ensembl:ENSECAP00000014584.2,
GN   ECO:0000313|VGNC:VGNC:24169};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014584.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000014584.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014584.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000014584.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014584.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004115}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC       {ECO:0000256|ARBA:ARBA00007104}.
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DR   AlphaFoldDB; F6YWV8; -.
DR   STRING; 9796.ENSECAP00000014584; -.
DR   PaxDb; 9796-ENSECAP00000014584; -.
DR   Ensembl; ENSECAT00000017912.3; ENSECAP00000014584.2; ENSECAG00000016918.4.
DR   VGNC; VGNC:24169; TMED4.
DR   GeneTree; ENSGT00940000159012; -.
DR   HOGENOM; CLU_066963_2_2_1; -.
DR   InParanoid; F6YWV8; -.
DR   OMA; GHAGRFT; -.
DR   TreeFam; TF314123; -.
DR   Proteomes; UP000002281; Chromosome 4.
DR   Bgee; ENSECAG00000016918; Expressed in testis and 23 other cell types or tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR22811:SF38; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        125..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          154..252
FT                   /note="GOLD"
FT                   /evidence="ECO:0000259|PROSITE:PS50866"
SQ   SEQUENCE   342 AA;  38453 MW;  9471DA4EDB1BE1A5 CRC64;
     MRRSYAGRGY LSVRAYSPSA RAAPPESWAQ ASACDLGERR PLASVGRDYA SGKLEDDSTN
     LGVWRMRTLR SAVLRGQEDR RRAVVTAHAR CAPGRTASPG SEAPARACAP GEGREMAGVG
     ARGRLVMGWP VLLLLALCAA GARGLYFHIG ETEKRCFIEE IPDETMVIGN YRTQMWDKQK
     EVFLPSTPGL GMHVEVKDPE GKVVLSRQYG SEGRFTFTSH TPGEHQICLH SNSTRMALFA
     GGRLRVHLDI QVGEHANNYP EIAAKDKLTE LQLRARQLLD QVEQIQKEQD YQRYREERFR
     LTSESTNQRV LWWSIAQTVI LILTGIWQMR HLKSFFEAKK LV
//
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