ID F6YX72_HORSE Unreviewed; 322 AA.
AC F6YX72;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN Name=OR52H20 {ECO:0000313|Ensembl:ENSECAP00000002598.3,
GN ECO:0000313|VGNC:VGNC:105432};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002598.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002598.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002598.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002598.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002598.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative odorant or sperm cell receptor.
CC {ECO:0000256|ARBA:ARBA00003929}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR AlphaFoldDB; F6YX72; -.
DR STRING; 9796.ENSECAP00000002598; -.
DR PaxDb; 9796-ENSECAP00000002598; -.
DR Ensembl; ENSECAT00000003715.3; ENSECAP00000002598.3; ENSECAG00000036725.2.
DR VGNC; VGNC:105432; OR52H20.
DR GeneTree; ENSGT01090000260043; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; F6YX72; -.
DR OMA; HSFHILI; -.
DR TreeFam; TF343679; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000036725; Expressed in trophoblast and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15221; 7tmA_OR52B-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF14; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU363047};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW Olfaction {ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Sensory transduction {ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363047}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 32..57
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 69..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 149..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 205..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 281..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT DOMAIN 50..301
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 322 AA; 36551 MW; F40996B644BE6831 CRC64;
MILEKTMMAT FNLSSFNSGP FILLGIPGLE QFHIWIGIPF FIIHLVALVS NSALLYLIYM
ERRLHEPMFF FLSILAATDL ILSNTCVPKT FSIFWIGPQE ITFPGCLTQM FFLHYSFAMD
SAILLAMAFD RYVAICFPLR YTTILTRQII TKIVIGIVSR SFCIIFPCVF LLKRLPFCQT
LIIPHTYCEH IGVAQLACAD ISINIWYGFA VPIVTVTSDL ILIGISYALI LHTIFNLPSQ
DARWKALNTC GSHVCVILIF YTPAMFSVLT HRFGHNIPHS FHILIANLYV AIPPALNPII
YGVKTKDIRE KIILLFFLRG TK
//
