ID F6YZA0_HORSE Unreviewed; 915 AA.
AC F6YZA0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=RAS protein activator like 3 {ECO:0000313|Ensembl:ENSECAP00000007180.3};
GN Name=RASAL3 {ECO:0000313|Ensembl:ENSECAP00000007180.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007180.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007180.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007180.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007180.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007180.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6YZA0; -.
DR STRING; 9796.ENSECAP00000007180; -.
DR PaxDb; 9796-ENSECAP00000007180; -.
DR Ensembl; ENSECAT00000009434.3; ENSECAP00000007180.3; ENSECAG00000009236.3.
DR GeneTree; ENSGT00940000161423; -.
DR HOGENOM; CLU_050165_0_0_1; -.
DR InParanoid; F6YZA0; -.
DR OMA; TWGSRSQ; -.
DR TreeFam; TF352183; -.
DR Proteomes; UP000002281; Chromosome 21.
DR Bgee; ENSECAG00000009236; Expressed in leukocyte and 18 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF96; RAS PROTEIN ACTIVATOR LIKE-3; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 188..308
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 362..554
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 68..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 795..892
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 104..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 99984 MW; 1BCCCC67F22C441A CRC64;
MCPSGTLGPS LCSMAGWCCW VVRRRVLAAH GLGVLALRAA SRRPWGTSGI QIGLLERPRQ
RLLAPTRSTM FGPADAPGHP GGKGAEEGAW SSAPLTSSSP QGLLKRLKEK KKARSELGAN
ASRDGPPSAL GSRESLATLS ELDLGAEREV RVWPLHPSLL EEPHCFQVTW AGGSRCFSCR
SAAERDRWIE DLRRHFQPSQ DNLEREETWL SVWVHEAKGL PRAAAGAPGV CAELWLDGAL
LARTAPRAGP GQLFWAERFH FEALPPARRL SLRLRGAGPG GPVLGRAALA LEELSVPRAP
AAGLERWFPL LGAPAGAALR ARIRARRLRV LPSERYKELA EFLTFHYARL CGALEPALSA
QAKEELAAAM VRVLQATGRA QALVTDLGTA ELARSGGREA LLFRENTLAT KAIDEYMKLV
AQDYLQETLG QIVRRLCASS EDCEVDPSKC QSAELPQHQA RLQNSCEEVF QSIVRSHDWF
PAELGTVFSG WREACKARGS EALGPRLVCA SLFLRLLCPA ILAPSLFGLA PEHPAPGPAR
ALTLIAKVIQ NLANRAPFGE KEAYMTFMNS FLEDHGPAMQ RFLDQVAMVD VDAAPSGYQG
SSDLALQLAV LHAQLCTIFA ELDQATRDSL EPLPTILHAI EEGRPVPVSV PMRLPPPPAQ
VHSSFSAGEK PGFLAPRDLP KHTPLISKSQ SLRSVQRAGS WARQRPDEER PRRLPRPVQR
TQSVPAGRPT RRRPSAGPRP RPQGSVRTGP VPRGRPWTGA SASLPRKPSV PWQRQLDQPR
DRDQALGTHR PMGKLAELQC EVAALREEQK TLSGLVESLS TDIRALTEQQ EQLRGQLQEL
DSRLREGTSQ LDPGHHPPSS EDHRLKSLER RLAELENAQV QLRDAVQNLQ LLPRTSGSRS
QPLALKAPCV NGDTT
//
