ID F6Z0A4_MONDO Unreviewed; 1216 AA.
AC F6Z0A4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004165.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000004165.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000004165.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC {ECO:0000256|ARBA:ARBA00006005}.
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DR AlphaFoldDB; F6Z0A4; -.
DR STRING; 13616.ENSMODP00000004165; -.
DR Ensembl; ENSMODT00000004253.2; ENSMODP00000004165.2; ENSMODG00000003404.2.
DR eggNOG; KOG0996; Eukaryota.
DR GeneTree; ENSGT00900000141094; -.
DR HOGENOM; CLU_001042_4_1_1; -.
DR InParanoid; F6Z0A4; -.
DR OMA; SEKNQNA; -.
DR TreeFam; TF101158; -.
DR Proteomes; UP000002280; Chromosome 5.
DR Bgee; ENSMODG00000003404; Expressed in spinal cord and 10 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 541..656
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 370..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 476..524
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 711..773
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 820..931
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1021..1058
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1216 AA; 139968 MW; 1964E102EDA58FE1 CRC64;
MINKEGTPRL MISHIVNLNF KSYAGRTQLG PFHKHFSCII GPNGSGKSNV IDSMLFVFGC
RAHKIRSKKL SVLIHHSDDY QDLDSCTVEV HFQKIIDKEG DDYEVIPNSS FYVSRTAYKN
NTSVYHISGK KQTFRDVGNL LRSHGIDLDH NRFLILQGEV EQIALMKPKG QSEHDEGMLE
YLEDIIGCGR LKEPIEVLSQ RLDVLTEERE EKLNRVKIVE KERNYLEIEK NLAIDFLTIE
NEILTKKNHI CQFYIYDLHK RIAEVEYEKD KILEETEAIK KKTSKLEGEM NAKTNALEEA
ERKLNQVATF IEENKEKYTQ LDLEGVQVKT KMKYAKTKAR KLEKQLQKDK EKVEEFKDVP
AKSEKVITET TTKKSTLEEE REKEEEKMKQ VMDSLKQETK ELQEEKESQE KELMEFNKTV
NEARSKMDVA QSELDIYLSH HNTAVSQLSE AQKALTTASE TLKERKTAIR DIEMKLPPTE
QDLKEKESEL QNLTKEARDL DSSIRDLLQK VEEAKSSLAT NQSRGKVLNA LIQQKLSGKI
QGIYGRLGDL GAIDEKYNIA ISSCCSALDY IVVNTIDTAQ VCVNFLKKQN IGVATFIGLD
KIKVLEKNMN PLQTPENIPR LFDLVKAKDE NIRRAFYFAL RDTLVADNLD QATRVAFQKD
KRWRVVTLQG QIIEQSGTMT GGGSKPMKGR MGSSLVMEVS EEEVANMESI LRRDSQRAIE
VQERKAQLEE AMIKLRHSVQ DMRNTLEKFT VSIQSLSEQE AYLNAQVKEL KANVCDTVPD
KNKQKFLETQ INTFKKEYEC VALKAGKVEA EVKRLHNLIM EINNHKLKSQ QDKLDKINKQ
LDQCASSITK AQVGVRTANR NLKKAQDSVL RTEKEITDND KEMEDFTQEL EDLEEKATEI
MKNSKEAGES LPEIQREHNN LVKEMKVIKE NECSLQNDAL SNKLKLEQVD SYIAEQHSKV
RFWEKEMSRI ALHPIENNQA EQISLLSQED LEEIGNPNFL NNQIELLESQ CNAMNPNLDS
IEEYKKKNQQ YLHRVAELEK ITIERDRYRR AYKDLRERRL NEFMAGFTII TNKLKENYQM
LTLGGDAELE LIDSLDPFSE GIMFSVRPPQ KSWKKIFNLS GGEKTLSSLA LVFALHDYKP
TPLYFMDEID AALDFKNVFI VAYYIYKQKK DAQFIIISLR NNMFEIADRL IGIYKTNNVT
KSVTINPKAI AAKGVC
//
