ID F6Z0D6_HORSE Unreviewed; 1067 AA.
AC F6Z0D6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Dishevelled associated activator of morphosis 2 {ECO:0000313|Ensembl:ENSECAP00000007744.2};
GN Name=DAAM2 {ECO:0000313|Ensembl:ENSECAP00000007744.2,
GN ECO:0000313|VGNC:VGNC:16993};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007744.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007744.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007744.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007744.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007744.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001500776.2; XM_001500726.5.
DR AlphaFoldDB; F6Z0D6; -.
DR Ensembl; ENSECAT00000010078.4; ENSECAP00000007744.2; ENSECAG00000009501.4.
DR GeneID; 100054194; -.
DR KEGG; ecb:100054194; -.
DR CTD; 23500; -.
DR VGNC; VGNC:16993; DAAM2.
DR GeneTree; ENSGT00940000157801; -.
DR OrthoDB; 5485896at2759; -.
DR TreeFam; TF314602; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000009501; Expressed in prefrontal cortex and 19 other cell types or tissues.
DR ExpressionAtlas; F6Z0D6; baseline.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 40..416
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 595..994
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1016..1047
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 514..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 688..715
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 965..1001
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1067 AA; 123316 MW; 5BEF389A36429638 CRC64;
MAPRKRSRHG LGFLCCFGGS DLPEINLRDN HPLQYMEFSS PIPNPEELNV RFAELVDELD
LTDKNREAVF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAFDE
EETEMRNQIV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL
RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
ELIHKKLKHT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDL
APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHTELVS RLERKERECE TKTLEKEEMM
RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSEISTGPVS SPPPPGGPLT LSSSMTTNDL
PPPPPPLPFV CCPPPPPPPL PPGGPPTPPG APPCFSMGLP LPPDPFPSSE TPLRKKCVPQ
PSHPLKSFNW VKLNEERVPG TVWNEIDDMQ VFRILDLEDF EKMFSAYQRH QKELGSTEDI
YLASRKVKEL SVIDGRRAQN CIILLSKLKL SNEEIRQAIL KMDEQEDLAK DMLEQLLKFI
PEKSDIDLLE EHKHEIERMA RADRFLYDMS RIDHYQQRLQ ALFFKKKFQE RLAEAKPKVE
AILLASRELV RSKRLTQMLE VVLAIGNFMN KGQRGGAYGF RVASLNKIAD TKSSIDRNIS
LLHYLIMILE KHFPDILNMP SELQHLPEAA KVNLAELEKE VGNLRRGLRA VEVELEYQKR
QMRDPNDKFV PVMSDFITVS SFSFSELEDQ LSEARDKFSK ALMHFGEHDS KMQPDEFFGI
FDTFLQAFSE ARQDLEAMRR KKEEEERRAR MEAMLKEQRE RERWQRQRKV HAGSTLEEGG
EFDDLVSALR SGEVFDKDLC KLKRSRKRSG SQALEVTRER AINRLNH
//
