ID F6Z1R7_HORSE Unreviewed; 348 AA.
AC F6Z1R7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Proline rich transmembrane protein 2 {ECO:0000313|Ensembl:ENSECAP00000021946.4};
GN Name=PRRT2 {ECO:0000313|Ensembl:ENSECAP00000021946.4,
GN ECO:0000313|VGNC:VGNC:112283};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021946.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021946.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021946.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021946.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021946.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR RefSeq; XP_001496375.2; XM_001496325.4.
DR AlphaFoldDB; F6Z1R7; -.
DR STRING; 9796.ENSECAP00000021946; -.
DR PaxDb; 9796-ENSECAP00000021946; -.
DR Ensembl; ENSECAT00000026319.4; ENSECAP00000021946.4; ENSECAG00000024472.4.
DR GeneID; 100065869; -.
DR KEGG; ecb:100065869; -.
DR VGNC; VGNC:112283; PRRT2.
DR GeneTree; ENSGT00940000161103; -.
DR HOGENOM; CLU_070349_0_0_1; -.
DR InParanoid; F6Z1R7; -.
DR OMA; DPQPDCQ; -.
DR TreeFam; TF331357; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000024472; Expressed in prefrontal cortex and 22 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14948; NG5; 1.
DR PANTHER; PTHR14948:SF20; PROLINE-RICH TRANSMEMBRANE PROTEIN 2; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..161
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 35706 MW; AE1E7254BC33398C CRC64;
MAASSSEISE MKGIEEGPQT QGEGSGHSEA RTGPLQVPAG VPDEPEALHP GPDITGAPVD
SEPKAGLAPE TTETPTGAPE TAQARDLSSS PGGESKANSS PKEACQEPAS KPEVSEEATA
DQGSDLESAA PLEPASEPTP QLGPQSVPQP DPHPGSQPTF KPALQPEPST QAEDPTPVLT
ESVGEKQENG VVVPLQAGDG EEGPAPQPHS PLSTNAPPAN GAPPRVLQQL VEEERLGKAH
RGHLGSPRGS LSRHPSSQLA GSGVEGGEGT QKPRDYIILA ILSCFCPMWP VNIVAFAYAV
MSRNSLQQGD VDGAQRLGRV AKLLSIVALV GGVLIIIASC VINLGVYK
//
