ID F6Z5H5_CALJA Unreviewed; 998 AA.
AC F6Z5H5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Nuclear factor NF-kappa-B p105 subunit {ECO:0000256|ARBA:ARBA00020838};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000256|ARBA:ARBA00032626};
GN Name=NFKB1 {ECO:0000313|Ensembl:ENSCJAP00000028399.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028399.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000028399.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000028399.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F6Z5H5; -.
DR STRING; 9483.ENSCJAP00000028399; -.
DR Ensembl; ENSCJAT00000030009.4; ENSCJAP00000028399.2; ENSCJAG00000015382.5.
DR GeneTree; ENSGT00940000158625; -.
DR InParanoid; F6Z5H5; -.
DR Proteomes; UP000008225; Chromosome 3.
DR Bgee; ENSCJAG00000015382; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08797; Death_NFkB1_p105; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07935; RHD-n_NFkB1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR047096; NF-kB_p105_DD.
DR InterPro; IPR030503; NF-kB_p105_RHD_N.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 69..276
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 611..643
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 644..667
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 680..712
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 714..747
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 748..780
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 455..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 109024 MW; C2E069F129C64025 CRC64;
MNSMVIEFLK FILVLQLCFV CFVLIYSFRM AEDDPYLGRP EQMFHLDPSL THTIFNPEVF
QPQMALPTAD GPYLQILEQP KQRGFRFRYV CEGPSHGGLP GASSEKNKKS YPQVKICNYV
GPAKVIVQLV TNGKNTHLHA HSLVGKHCED GICTVTAGPK DMVVGFANLG ILHVTKKKVF
ETLEARMTEA CIRGYNPGLL VHPDLAYLQA EGGGDRQLGD REKELIRQAA LQQTKEMDLS
VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY DSKAPNASNL KIVRMDRTAG CVTGGEEIYL
LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF SPTDVHRQFA IVFKTPKYKD VNITKPASVF
VQLRRKSDLE TSEPKPFLYY PEIKDKEEVQ RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS
GSGGGGTGST GPGYSFPHYG FPTYGGISFH PGTTKSNAGM KHGAMDSESK TDPEGCDKSD
DRDTVNLCRK VTETTEQDQE PSKATDGNGE VTLTYATGTK EENAEVQDNL FLEKAMQLAK
RHANALFDYA VTGDVKMLLA VQRHLTAVQD ENGDSVLHLA IIHLHSQLVR DLLEVTSGLI
SDDIINMRND LYQTPLHLAV ITKQEDVVED LLRAGADLSL LDRFGNSVLH LAAKEGNDKV
LSILLKHKKA ALLLDYPNGD GLNAIHLAMM SNSLPCLLLL VAAGANVNAQ EQKSGRTALH
LAVEHDNISL AGCLLLEGDA HVDSTTYDGT TPLHIAAGRG STRLAALLKA AGADPLVENF
EPLYDLDDSW ENAGEDEGVV SGTTPLDMAT SWQVFDILNG KPYEPEFTSD DLLAQGDMKQ
LAEDVKLQLY KLLEIPDPDK NWATLAQKLG LGILNNAFRL SPAPSKTLMD NYEVSGGTVR
ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ AHSLPLSPAS TRQQIDELRD SDSVCDSGVE
TSFHKLSFTE SLTSGGSLLT LNKMPHDYGQ EGPLEGKI
//
