ID F6Z5V4_HORSE Unreviewed; 330 AA.
AC F6Z5V4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Interleukin 1 receptor associated kinase 1 binding protein 1 {ECO:0000313|Ensembl:ENSECAP00000007158.3};
GN Name=IRAK1BP1 {ECO:0000313|Ensembl:ENSECAP00000007158.3,
GN ECO:0000313|VGNC:VGNC:112225};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007158.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007158.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007158.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007158.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007158.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the IRAK1BP1 family.
CC {ECO:0000256|ARBA:ARBA00005509}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6Z5V4; -.
DR STRING; 9796.ENSECAP00000007158; -.
DR PaxDb; 9796-ENSECAP00000007158; -.
DR Ensembl; ENSECAT00000009409.3; ENSECAP00000007158.3; ENSECAG00000009253.3.
DR VGNC; VGNC:112225; IRAK1BP1.
DR GeneTree; ENSGT00390000012588; -.
DR HOGENOM; CLU_121988_0_0_1; -.
DR InParanoid; F6Z5V4; -.
DR OMA; TQTATRE; -.
DR OrthoDB; 2943966at2759; -.
DR TreeFam; TF328455; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000009253; Expressed in testis and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR Gene3D; 3.30.110.170; Protein of unknown function (DUF541), domain 1; 1.
DR Gene3D; 3.30.70.2970; Protein of unknown function (DUF541), domain 2; 1.
DR InterPro; IPR030312; IRAK1BP1.
DR InterPro; IPR007497; SIMPL/DUF541.
DR PANTHER; PTHR18842; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR18842:SF2; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1; 1.
DR Pfam; PF04402; SIMPL; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SQ SEQUENCE 330 AA; 36253 MW; B6D81C932D64325D CRC64;
MSLQQAPPSR VFVELVPWAE RGREDNLVSG GETQPGLRRA LPSAQAQTAA REVHVSGAAE
VSAGPDRAQV AVRVSSAKEA AAEAKKSVGR RLDYITQSLQ QQGVQAENVT VTKDFRRVEN
AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSLENL RRQACLVAVE
NAWRKAQEVC HLVGQTLGKP LLIKEEETKE WEGQTDDHQS SSLSNASSVQ QKIKSATLYA
ASKEDVSVSA TLRDPRFQHG SQQSLPVSHV TRIGSPVPPQ NEQMLALVFK CTLLFLQSLA
FSEKKSVAMQ QHAVCCLNSS LQLCQNVHAF
//
