ID F6Z6K1_HORSE Unreviewed; 396 AA.
AC F6Z6K1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cell adhesion molecule 3 {ECO:0000313|Ensembl:ENSECAP00000007702.3};
GN Name=CADM3 {ECO:0000313|Ensembl:ENSECAP00000007702.3,
GN ECO:0000313|VGNC:VGNC:16000};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007702.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007702.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007702.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007702.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007702.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR AlphaFoldDB; F6Z6K1; -.
DR Ensembl; ENSECAT00000010024.4; ENSECAP00000007702.3; ENSECAG00000009553.4.
DR VGNC; VGNC:16000; CADM3.
DR GeneTree; ENSGT00940000159779; -.
DR HOGENOM; CLU_047574_1_0_1; -.
DR TreeFam; TF326804; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000009553; Expressed in prefrontal cortex and 15 other cell types or tissues.
DR ExpressionAtlas; F6Z6K1; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05882; IgV_1_Necl-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR45889:SF5; CELL ADHESION MOLECULE 3; 1.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..396
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040120195"
FT TRANSMEM 327..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..313
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 365..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 43181 MW; 100615BD3892C823 CRC64;
MGAPSALPLL LLFACCWAPG GANLSQDDSQ PWTSDETVVA GGTVVLKCQV KDHEDSSLQW
SNPAQQTLYF GEKRALRDNR IQLVRSTPHE LSISISNVAL ADEGEYTCSI FTMPVRTAKS
LVTVLGVPQK PTISGYKSSL REKETTTLKC QSSGSKPAAQ LTWRKGDQEL HGELTQVQED
PNGKTFTVSS SVTFQVTRED DGADIICSVN HESLKGADRS TAQRIEVLYT PTAEIRPDPP
KPREGQKLLL HCEGRGNPVP QQYLWEKEGS EPPLKMTQES ALIFPFLNKS DSGTYGCTAT
SNMGSYKAYY ILNVHDPSPV PSSSSTYHAI IGGIVAFIVF LLLILLIFLG HYLIRHKGTY
LTHEAKGSDD APDADTAIIN AEGGQSGGDD KKEYFI
//