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Database: UniProt
Entry: F6Z7T2_MACMU
LinkDB: F6Z7T2_MACMU
Original site: F6Z7T2_MACMU 
ID   F6Z7T2_MACMU            Unreviewed;       930 AA.
AC   F6Z7T2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Nuclear factor of activated T cells 1 {ECO:0000313|Ensembl:ENSMMUP00000029747.4};
GN   Name=NFATC1 {ECO:0000313|Ensembl:ENSMMUP00000029747.4,
GN   ECO:0000313|VGNC:VGNC:75326};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029747.4, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000029747.4, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029747.4,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA   Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA   Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA   Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA   Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA   Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA   Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA   Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA   Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA   Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA   Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA   Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA   Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA   Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA   Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA   Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA   Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA   Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA   Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA   Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA   Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA   Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA   Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA   Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA   Kuhn R.M., Smith K.E., Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000029747.4}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029747.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_001088054.2; XM_001088054.3.
DR   AlphaFoldDB; F6Z7T2; -.
DR   PaxDb; 9544-ENSMMUP00000029747; -.
DR   Ensembl; ENSMMUT00000031795.4; ENSMMUP00000029747.4; ENSMMUG00000022596.4.
DR   GeneID; 698089; -.
DR   KEGG; mcc:698089; -.
DR   CTD; 4772; -.
DR   VEuPathDB; HostDB:ENSMMUG00000022596; -.
DR   VGNC; VGNC:75326; NFATC1.
DR   eggNOG; ENOG502QTX8; Eukaryota.
DR   GeneTree; ENSGT00940000157616; -.
DR   HOGENOM; CLU_010185_1_0_1; -.
DR   OrthoDB; 5405363at2759; -.
DR   TreeFam; TF326480; -.
DR   Proteomes; UP000006718; Chromosome 18.
DR   Bgee; ENSMMUG00000022596; Expressed in hindlimb stylopod muscle and 22 other cell types or tissues.
DR   ExpressionAtlas; F6Z7T2; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR   CDD; cd07881; RHD-n_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transcription {ECO:0000256|ARBA:ARBA00023015};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          397..579
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          54..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          744..763
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          770..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          857..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        797..812
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   930 AA;  100304 MW;  05D050C1D6676AFB CRC64;
     MTGLEDQEFD FEFLFEFNQR DEGAAAAAPE HYGYASSNVS PALPLPTAHS TLPAPCHNLQ
     TSTPGIVQPA DHPSGYGAAL DGGPTGYFLS SGHARPDGAP ALESPRIEIT SCLGLYHNNN
     QFFHDVEVED VLPSSKRSPS TATLSLPSLE AYRDPSCLSP ASSLSSRSCN SEASSYESNY
     SYPYASPQTS PWQSPCVSPK TTDPEEGFPR GLGACTLLGS PRHSPSTSPR ASVTEESWLG
     ARSSRPASPC NKRKYSLNGR QPPYSPHHSP TPSPHGSPRV SVTDDSWLGN TTQYTSSAIV
     AAINALTTDS SLDLGDGVPV KSRKTTLEQP PSVALKVEPV GEDLGSPPPP ADFAPEDFSS
     FQHIRKGGFC DQYLAVPQHP YQWAKPKPLS PASYMSPTLP ALDWQLPSHS GPYELRIEVQ
     PKSHHRAHYE TEGSRGAVKA SAGGHPIVQL HGYLESEPLM LQLFIGTADD RLLRPHAFYQ
     VHRITGKTVS TTSHEAILSN TKVLEIPLLP ENSMRAVIDC AGILKLRNSD IELRKGETDI
     GRKNTRVRLV FRVHVPQPSG RTLSLQVASN PIECSQRSAQ ELPLVEKQST DSYPVMGGKK
     MVLSGHNFLQ DSKVIFVEKA PDGHHVWEME AKTDRDLCKP NSLVVEIPPF RNQRITSPVH
     VSFYVCNGKR KRSQYQRFTY LPANVPMIKT EPTDDYEPAP NCGPVSQGLS PLPRPYYSQQ
     LAMPPDPSSC LVAGFPPCPQ RSTLMPAAPG ASPKLHDLSP AAYTKGVTSP GHCHLGLPQP
     AGEAPAVQDV PRPVATHPGS PGQPPPALLP QQVSVPPSSS CPPGLEHSLC PSSPSPPLPP
     AAQELTCLQP CSPACPPATG RPQHPPPTVR RDESPAAQPR LLPEACEDSS PNLAPIPVTV
     KQEPEELDQL YLDDVNEIIR NDLSGTSTHS
//
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