ID F6Z7T2_MACMU Unreviewed; 930 AA.
AC F6Z7T2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Nuclear factor of activated T cells 1 {ECO:0000313|Ensembl:ENSMMUP00000029747.4};
GN Name=NFATC1 {ECO:0000313|Ensembl:ENSMMUP00000029747.4,
GN ECO:0000313|VGNC:VGNC:75326};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029747.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000029747.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029747.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029747.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029747.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_001088054.2; XM_001088054.3.
DR AlphaFoldDB; F6Z7T2; -.
DR PaxDb; 9544-ENSMMUP00000029747; -.
DR Ensembl; ENSMMUT00000031795.4; ENSMMUP00000029747.4; ENSMMUG00000022596.4.
DR GeneID; 698089; -.
DR KEGG; mcc:698089; -.
DR CTD; 4772; -.
DR VEuPathDB; HostDB:ENSMMUG00000022596; -.
DR VGNC; VGNC:75326; NFATC1.
DR eggNOG; ENOG502QTX8; Eukaryota.
DR GeneTree; ENSGT00940000157616; -.
DR HOGENOM; CLU_010185_1_0_1; -.
DR OrthoDB; 5405363at2759; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000006718; Chromosome 18.
DR Bgee; ENSMMUG00000022596; Expressed in hindlimb stylopod muscle and 22 other cell types or tissues.
DR ExpressionAtlas; F6Z7T2; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 397..579
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 54..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..812
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 100304 MW; 05D050C1D6676AFB CRC64;
MTGLEDQEFD FEFLFEFNQR DEGAAAAAPE HYGYASSNVS PALPLPTAHS TLPAPCHNLQ
TSTPGIVQPA DHPSGYGAAL DGGPTGYFLS SGHARPDGAP ALESPRIEIT SCLGLYHNNN
QFFHDVEVED VLPSSKRSPS TATLSLPSLE AYRDPSCLSP ASSLSSRSCN SEASSYESNY
SYPYASPQTS PWQSPCVSPK TTDPEEGFPR GLGACTLLGS PRHSPSTSPR ASVTEESWLG
ARSSRPASPC NKRKYSLNGR QPPYSPHHSP TPSPHGSPRV SVTDDSWLGN TTQYTSSAIV
AAINALTTDS SLDLGDGVPV KSRKTTLEQP PSVALKVEPV GEDLGSPPPP ADFAPEDFSS
FQHIRKGGFC DQYLAVPQHP YQWAKPKPLS PASYMSPTLP ALDWQLPSHS GPYELRIEVQ
PKSHHRAHYE TEGSRGAVKA SAGGHPIVQL HGYLESEPLM LQLFIGTADD RLLRPHAFYQ
VHRITGKTVS TTSHEAILSN TKVLEIPLLP ENSMRAVIDC AGILKLRNSD IELRKGETDI
GRKNTRVRLV FRVHVPQPSG RTLSLQVASN PIECSQRSAQ ELPLVEKQST DSYPVMGGKK
MVLSGHNFLQ DSKVIFVEKA PDGHHVWEME AKTDRDLCKP NSLVVEIPPF RNQRITSPVH
VSFYVCNGKR KRSQYQRFTY LPANVPMIKT EPTDDYEPAP NCGPVSQGLS PLPRPYYSQQ
LAMPPDPSSC LVAGFPPCPQ RSTLMPAAPG ASPKLHDLSP AAYTKGVTSP GHCHLGLPQP
AGEAPAVQDV PRPVATHPGS PGQPPPALLP QQVSVPPSSS CPPGLEHSLC PSSPSPPLPP
AAQELTCLQP CSPACPPATG RPQHPPPTVR RDESPAAQPR LLPEACEDSS PNLAPIPVTV
KQEPEELDQL YLDDVNEIIR NDLSGTSTHS
//