ID F6Z7V1_ORNAN Unreviewed; 983 AA.
AC F6Z7V1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=BicC family RNA binding protein 1 {ECO:0000313|Ensembl:ENSOANP00000020891.4};
GN Name=BICC1 {ECO:0000313|Ensembl:ENSOANP00000020891.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000020891.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000020891.4, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020891.4,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000020891.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020891.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
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DR AlphaFoldDB; F6Z7V1; -.
DR STRING; 9258.ENSOANP00000020891; -.
DR Ensembl; ENSOANT00000020894.4; ENSOANP00000020891.4; ENSOANG00000013223.5.
DR eggNOG; KOG2208; Eukaryota.
DR eggNOG; KOG4374; Eukaryota.
DR GeneTree; ENSGT00940000156276; -.
DR HOGENOM; CLU_008040_0_0_1; -.
DR InParanoid; F6Z7V1; -.
DR OMA; PDNDTPY; -.
DR TreeFam; TF323767; -.
DR Proteomes; UP000002279; Chromosome 3.
DR Bgee; ENSOANG00000013223; Expressed in adult mammalian kidney and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd22420; KH-I_BICC1_rpt1; 1.
DR CDD; cd22421; KH-I_BICC1_rpt2; 1.
DR CDD; cd22422; KH-I_BICC1_rpt3; 1.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 3.30.310.270; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR047549; BICC1_KH-I_rpt1.
DR InterPro; IPR047554; BICC1_KH-I_rpt2.
DR InterPro; IPR047553; BICC1_KH-I_rpt3.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR10627:SF78; PROTEIN BICAUDAL C HOMOLOG 1; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 882..945
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 105207 MW; 676E5ACBA088741F CRC64;
MAAQGEPGPA GQRGARSPGP PSPEDQPGYG PGGPGGPGGS GGPGGSGGQG PPHSPEWGEE
RFRVDRKKLE AMLQAAAEGK GKSGEDFFQK IMEETNTQIA WPSKLKIGAK SKKDPHIKVS
GKKENVKEAK ERIMSVLDTK SNRVTLKMDV SHTEHSHVIG KGGNNIKKVM EETGCHIHFP
DSNRNNQAEK SNQVSIAGQP AGVESARVRI RELLPLVLMF ELPIAGILQP IPDPNSPTIQ
HISQTYNISV SFKQRSRMYG ATVIVRGSQN NTSAVKEGTA MLLEHLAGSL ASAILVSTQL
DIAAQHHLFM MGRNGSNIKH IMQRTGAQIH FPDPNNPQKK STVYLQGTIE SVCLARQYLM
GCLPLVLMFD MKEEIEVEAQ FIAQLMEQLD VFISIKPKPK QPSKSVIVKS VERNALNMYE
ARKCLLGLES SGVAITTNPP AVSCPAGLSC PGLDILASAG LGLTGLGLLG PTTLSVNTST
PNSLLNALNG SVSPLQSPSS GTPSPTLWAP PLANASSATG FSSIPHLMIP STAQATLTSI
LLSGVPNYSQ TTPSPPPGLT PVEVHVNGLQ SEGQTVSSCL NGHVQPPNLK YGTLSTSALG
DKVLSANHGD PSLQTSNSEQ VSTKSNTPEG CNDAFVEVGM PRSPSHSASA SELKQMMSSS
KVSCSKRQTV ELLQGTKNSH LHTTDRLLSD SDLSAAESPL ADKKAPGSER AAERAAAAQQ
NSERVRLAPR TSYVNMQAFD YEQKKLLATK AMLKKPVVTE VRTPTNTWSG LGFSKSMPAE
TIKELRRANH VSYKPTMTTT YEGPSLSLSR SNSREYLGSG RESDSWRDRN GMGPSPSELA
ASIGSPKRKQ NKSTEHYLSS SNYMDCISSL TGSNGCNLNS SFKGSDLPEL FSKLGLGKYT
DVFQQQEIDL QTFLTLTDQD LKELGITTFG ARRKMLLAIS ELNKNGRKLF DPPNARASFL
EGGASGRLPR QYHADIASVS GRW
//
