ID F6Z8P9_MONDO Unreviewed; 1154 AA.
AC F6Z8P9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Exportin-4 {ECO:0000256|ARBA:ARBA00040444};
GN Name=XPO4 {ECO:0000313|Ensembl:ENSMODP00000010266.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000010266.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000010266.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000010266.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
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DR AlphaFoldDB; F6Z8P9; -.
DR STRING; 13616.ENSMODP00000010266; -.
DR Ensembl; ENSMODT00000010464.3; ENSMODP00000010266.2; ENSMODG00000008262.4.
DR eggNOG; KOG4541; Eukaryota.
DR GeneTree; ENSGT00940000153139; -.
DR HOGENOM; CLU_005818_0_0_1; -.
DR InParanoid; F6Z8P9; -.
DR OMA; SCKSIFH; -.
DR TreeFam; TF312991; -.
DR Proteomes; UP000002280; Chromosome 4.
DR Bgee; ENSMODG00000008262; Expressed in spermatocyte and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014877; XPO1_C_dom.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; EXPORTIN 4,7-RELATED; 1.
DR PANTHER; PTHR12596:SF1; EXPORTIN-4; 1.
DR Pfam; PF08767; CRM1_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 966..1074
FT /note="Exportin-1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08767"
SQ SEQUENCE 1154 AA; 130454 MW; 4AA031FF70009FCC CRC64;
MMAAALGPPE VIAQLENAAK VLMAPPSMVN NEQRQHAEHI FLSFRKSKSP FAVCKHILET
SKVDYVLFQA ATAIMEAVVR EWILLEKSSI ESLRTFLLTY VLQRPNLQKY VREQILLAVA
VIVKRGSLDK SIDCKSIFHE VSQLISSGNP TVQTLACSIL TALLSEFSSS SKTSNIGLSM
EFHGNCKRIF QEEDLRQIFM LTVEVLQEFS RRENLNAQMS SVFQRYLALA NQVLSWNFLP
PNYILLMTED MVTMFESSQN VMLKPTESWR ETLLDSRVMD LFFTVHRKIR EDSDMAQDSL
QCLAQLASLH GPIFPDEGSQ VDYLAHFIEG LLNTINGIEI EDSEAVGISS IISNLITVFP
RNILTAIPNE LFSSFVNCLT HLTCSFGRSA ALEEVLDKDD MVYMEAYDKL LESWLTLVQD
DKHFHKGFFT QHAVQVFNSY IQCHLAAPDG TRNLTANGVA SREEEEISEL QEDDRDQFSD
QLASVGMLGR IAAEHCIPLL TSLLEDRVTR LHGQLQRHQQ QLLASPGSGA IDNKVLDDLY
EDIHWLILVT GYLLADDTQG ETPLIPPEVM DYSIKQSTEV DINTTLQILG SPGEKASSIP
GCNRTDSVIR LLSAILRVSE VESRAIRANL THLLSPQMGK DIVWFLKRWA KTYLLVDEKL
YDQISLPFNT AFGADTEGSQ WIVGYLLEKV ISNLAVWSSE QDLANDTVQL LVTLVERRER
ANLVIKCENW WNLAKQFARR SPPLHLLSSS VQRTLMKALV LGGFAHMDTD TKQQYWTEVL
QPLQQRFLNV INQENFQQIC QEEEVKQEIT ATLEALCGIA EATQIDNVAI LFNFLMDFLT
NCIGLMEVYK NTPETVNLII EVFVEVAHKQ ICYLGESKAM NLYEACLTLL QVYSKNNLGR
QRIDVTAEEE QYQDLLLIME LLTNLLSKEF IDFSDTDDVF RHEPGQAANR SVSAADVVLY
GVNLILPLMS QDLLKFPTLC NQYYKLITFI CEIFPEKIPQ LPEDLFKSLM YSLELGMTSM
SSEVCQLCLE ALTPLAEQCA KAQETDSPLF LATRHFLKLV FDMLVLQKHN TEMTTAAGEA
FYTLVCLHQA EYSELVETLL SSQQDPVIYQ RLADAFNKLT ASSTPPTLDR KQKMAFLKSL
EEFMANVGGL LCVK
//
