ID F6Z9J5_CIOIN Unreviewed; 732 AA.
AC F6Z9J5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000256|ARBA:ARBA00021116};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000011133.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000011133.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family.
CC {ECO:0000256|ARBA:ARBA00006128}.
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DR EMBL; EAAA01002669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6Z9J5; -.
DR STRING; 7719.ENSCINP00000011133; -.
DR Ensembl; ENSCINT00000011133.3; ENSCINP00000011133.3; ENSCING00000005410.3.
DR GeneTree; ENSGT00390000001566; -.
DR HOGENOM; CLU_022078_0_0_1; -.
DR InParanoid; F6Z9J5; -.
DR OMA; KMYLVNA; -.
DR TreeFam; TF317339; -.
DR Proteomes; UP000008144; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IBA:GO_Central.
DR GO; GO:0031313; C:extrinsic component of endosome membrane; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0141039; F:phosphatidylinositol 3-kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0045022; P:early endosome to late endosome transport; IBA:GO_Central.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; UNCHARACTERIZED; 1.
DR PANTHER; PTHR13083:SF3; WD REPEAT-CONTAINING PROTEIN 91; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 396..437
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 533..601
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 587..622
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 236..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 81785 MW; C71F6A1338F91FFB CRC64;
MSWTSSTGLM DSLVRDYLLQ RGFNSALKSF DFDSKNDKEK GFRVDKILQY ILSMVASCDL
DSLRSYWSHL DQRLFCLLGE QAQTSTVKKM EFNLYRYYIV NALQNGKRKE CFEFYEKMST
ELQNLPEWKD WFSFPFTPHP ESNKLYSNYF TKQWSDTFLV SLQNFLAVTF SCLPAPDLLS
SFNKDQATID KLESENELLR LTLSEININP VLREENKIPN YVRGLGVPGA LVENEPSTVQ
TQKKKSAFSF PSKKTTTTTP TTTSPKLNKQ LKTTQQQQQP KQLPKQIIFL NLITDPPIKP
TAPNTQIEQP PPTIQPASDN LMQRNKKLSG YQNQRRELFG VCNTSRSIDL DPQIKPPKSD
PPASQSNPTP NLPKESDQPP ESASNEPFLK LSKDEYHDHH SSIMQCRFNP QGNSIASVDK
DGVVKIWQFE PNPVTIATVM SRSPFLSLDW HTSATDLVLL GSSNGTIKIY NAASKVSQHD
VNISGNCPRV NQLSCHPGGT SFVTSCISNG GFGGYTPNTQ DVNTPGRVQI WDINESQVTL
DSSLQECSDR HIECLAYSKD GNYLATGDSK GKLTVFDTRT YKLMQSRQAH SGPIYTVQFS
QDERFVFTLG ADGKFCAWNL ASPIEPTIFP IHASAGGPFE VTGFSGYKQV QQPGGGRLFA
FEPNGNHVMT CDGPSAVVYE VNISLGTLKK VLTLVDHRSP VLSLDWTSAL KCAYCMTGGM
DGKVNVTTLL KK
//
