ID F6Z9U4_ORNAN Unreviewed; 245 AA.
AC F6Z9U4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Carboxymethylenebutenolidase homolog {ECO:0000256|ARBA:ARBA00014180};
GN Name=CMBL {ECO:0000313|Ensembl:ENSOANP00000018369.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000018369.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000018369.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018369.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000018369.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000018369.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the dienelactone hydrolase family.
CC {ECO:0000256|ARBA:ARBA00008456}.
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DR RefSeq; XP_001515235.1; XM_001515185.4.
DR AlphaFoldDB; F6Z9U4; -.
DR STRING; 9258.ENSOANP00000018369; -.
DR ESTHER; ornan-f6z9u4; CMBL.
DR Ensembl; ENSOANT00000018372.3; ENSOANP00000018369.2; ENSOANG00000011594.3.
DR GeneID; 100089878; -.
DR KEGG; oaa:100089878; -.
DR CTD; 134147; -.
DR eggNOG; KOG3043; Eukaryota.
DR GeneTree; ENSGT00390000000183; -.
DR HOGENOM; CLU_054590_8_2_1; -.
DR InParanoid; F6Z9U4; -.
DR OMA; HIKAYVV; -.
DR OrthoDB; 4496509at2759; -.
DR TreeFam; TF331795; -.
DR Proteomes; UP000002279; Chromosome X3.
DR Bgee; ENSOANG00000011594; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR042946; CMBL.
DR InterPro; IPR002925; Dienelactn_hydro.
DR PANTHER; PTHR46812; CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG; 1.
DR PANTHER; PTHR46812:SF1; CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG; 1.
DR Pfam; PF01738; DLH; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 30..244
FT /note="Dienelactone hydrolase"
FT /evidence="ECO:0000259|Pfam:PF01738"
SQ SEQUENCE 245 AA; 28057 MW; 3E96179EECA851B1 CRC64;
MANEAQPCPC DIGHKMEYGG MGSEVPVEHI QAYLCKPPSS TDKAVIVVQD IFGWQMPNTR
YIADMIAANG YTVICPDFFV GKEPWQPNDD WSTFQDWLKT RNARNVDKEA DAVLKYLKKH
CNAKKIGIVG FCWGGVVVHH LMVKYPDFKA GVSVYGIIKD TEDVYALNNP TLFIFGEKDT
VIPLEQINVL EKKLKEHCKV DYQIKIFPGQ THGFVHRKRE DCKPEDRSCI EESRKNLIDW
LNKYI
//
