ID F6ZAJ5_HORSE Unreviewed; 1021 AA.
AC F6ZAJ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN Name=LOC102148739 {ECO:0000313|Ensembl:ENSECAP00000016221.2};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000016221.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000016221.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016221.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000016221.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000016221.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; F6ZAJ5; -.
DR Ensembl; ENSECAT00000019791.3; ENSECAP00000016221.2; ENSECAG00000003988.4.
DR GeneTree; ENSGT00940000164181; -.
DR HOGENOM; CLU_002274_4_6_1; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000003988; Expressed in liver and 18 other cell types or tissues.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690:SF3; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 82..215
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1021 AA; 115288 MW; 67A4C969FC89B514 CRC64;
MRVCGWPHRD YREVFRKHLK EKYLKIGVDK CYHHGKHIES RLLVVKEHCI SEEASCGIPQ
QDNFIEMEHV FDPDEEGSSS SRTVVLQGCA GTGKTAVVHK FMFDWAAGTV TPGRFDYLIY
VNCREISHIA NLSAADLITN TFQDINGPIL DVTLMYPEKL LFILDGFPEL QHTIGDQEED
LSANPQERKP VETLLCSFVR KKLFPESSLL ITARPTTMKK LHSLLKQPIQ AEILWFTDAE
KRAYFLSQFL GANTAMRVFY DLRESEGLDI MSSLPIISWM ICSVLQSQGD DDRTLMRSLQ
TMTDVYLFYF SKCLKTLTGV SVWKGQSCLW GLCSLAAKGL QNQQVLFEVS DLRRHGIGVY
DTNCTFLNHF LKKAEGGVNV YTFLHFSFQE FLTAVFYALK NDSSWMFFDQ VGKTWQEIFQ
QYGKGFSSLT IQFLFGLLHK GKGKALETTF GRKVSPGLRE ELLKWTEKEI KDKSSRLQIE
PMDLFHCLYE IQEEEYAKRI IGDLNSIILL QPTYTKMDIL AMSFCVKSSH SHLSVTLKCQ
HLLGFEEEER ASAFMPPALT LNQSFQLCNL PVSRLHLLCQ VLRNPDCKIR DLKLIFCRLT
ASCGRDLSLV FETNQCLTNL EFVKNTLEDS GVKLLCQGLK HSNCILQTLR LYRCLISPAS
CEALAAVLST SQWLTELEVS ETKLETSAFK FLCEGLKDPN CKLQKLKLCD SILPESSEAV
CKYLASVLIC NPHLTELDLS ENPLGDTGVK YLCEGLRHSN CKVEKLDLST CHLTDASCVE
LSSFLQVSQT LKELIVFANA LGDTGVQHLC GGLRHTKGII ENLVLSECSL SAACCESLAQ
VLRSTWSLTR LLLINNKIED LGLKLLCEGL KQPDCQLKDL ALWTCNLTGE CCQDLCNALY
TNEQLRVLDL SDNALGDEGM QVLCEGLKQP SCKLQTLWLA QCHLTDACSG ALASVLNRNE
NLTLLDLSGN DFKDFGVQML CDALIHPICK LQEFYIDTDH LHEETLRKME ALKISKPGIT
W
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