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Database: UniProt
Entry: F6ZAY6_XENTR
LinkDB: F6ZAY6_XENTR
Original site: F6ZAY6_XENTR 
ID   F6ZAY6_XENTR            Unreviewed;       903 AA.
AC   F6ZAY6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 3 {ECO:0000313|Ensembl:ENSXETP00000033593};
GN   Name=itpr3 {ECO:0000313|Ensembl:ENSXETP00000033593,
GN   ECO:0000313|Xenbase:XB-GENE-1012312};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000033593, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000033593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000033593};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000033593}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   EMBL; AAMC01054944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000033593; -.
DR   PaxDb; F6ZAY6; -.
DR   Ensembl; ENSXETT00000033593; ENSXETP00000033593; ENSXETG00000015377.
DR   Xenbase; XB-GENE-1012312; itpr3.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   OMA; RKYLCID; -.
DR   Reactome; R-XTR-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-XTR-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-XTR-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-XTR-5578775; Ion homeostasis.
DR   Reactome; R-XTR-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000015377; Expressed in 9 organ(s), highest expression level in embryo.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    374       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      380    436       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    110       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   903 AA;  103478 MW;  69E29E7E9E94A54B CRC64;
     MSEMSSFLHI GDIVSLYAEG TVCGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFRVC
     PMNRYSAQKQ YWKAKQAKQD KEKISDVLLL QKLQHAANLE QKQNETENKK VHGEVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDVTGNEGS WFFIQPFWKL RSNGDNVVVG
     DKVNLNPVNA GQPLHASNYE LTDNPGCKEV NSLNSNTSWK INLFMQYRDY MEDVLKGGDV
     VRLFHAEQEK FLTCDEYKSR LHVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NSLYRFKHLA TGHYLAAEEN PAYKGDAPEF KSGSSNAVVS TRPSRKNAGE KIKFRLVAVP
     HGNDIASLFE LDPTTLQKTD SLVPRNSFVR LRHLCTNTWI QSTNVPIDVD EERPIRLMLG
     TCPTKEDKEA FAIVSVPVSE IRDLDFANDA SSMLANFVER LNEGFISQND RRFAIKLLED
     LVFFVVDVSN NGQNVLDIMI TKPNRERQKL MREQNILKQS MFQIILYSYQ EFPIDCKSVA
     TLHNIHRQKS SGYSGCFPLS CYRYLDYSQD DYQRKGKEQV TQSYSIVGSG RKEESEPDLV
     IVSLAGSVKW IESKGEAESF TGVHRSNKAP RRFLDYLSDL CVSNHIAIPV TQELICKCVL
     DPKNSDILIK TELRPLKEMS PEYMSLEYCD EEVWLTWTDK NNDSHEKSIR QLSQEARAGN
     AHDENVLTYY RYQLKLFARM CLDRQYLAIH EISKQLSVDL IFLCMADEML PYEIRASFCH
     LMLHVHVDRD PQELVTPVKF ARLWTEIPMA ITIKDYDSNL NDSRDNKKNK FTSTMEFVED
     YLNNVVSESM PFSHEDKNKL TFEVVSLARH LIYFGFYSFS ELLRLTRTLL GIIDCVQNPQ
     SIL
//
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