ID F6ZBK2_HORSE Unreviewed; 664 AA.
AC F6ZBK2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Cadherin related family member 5 {ECO:0000313|Ensembl:ENSECAP00000007851.3};
GN Name=CDHR5 {ECO:0000313|Ensembl:ENSECAP00000007851.3,
GN ECO:0000313|VGNC:VGNC:59242};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007851.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007851.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007851.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007851.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007851.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6ZBK2; -.
DR STRING; 9796.ENSECAP00000007851; -.
DR PaxDb; 9796-ENSECAP00000007851; -.
DR Ensembl; ENSECAT00000010204.3; ENSECAP00000007851.3; ENSECAG00000009824.4.
DR VGNC; VGNC:59242; CDHR5.
DR GeneTree; ENSGT00940000162463; -.
DR HOGENOM; CLU_021415_0_0_1; -.
DR InParanoid; F6ZBK2; -.
DR OMA; PDYEANT; -.
DR TreeFam; TF350567; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000009824; Expressed in adult mammalian kidney and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.40.60; Cadherins; 4.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF414; CADHERIN-RELATED FAMILY MEMBER 5 ISOFORM X1-RELATED; 1.
DR Pfam; PF00028; Cadherin; 1.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..664
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040372997"
FT TRANSMEM 481..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..231
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 348..457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 449..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..580
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 70733 MW; 5AEE97C6C9492783 CRC64;
MGAWVLLLPL LMAMAQAQAQ AQVCSVAKNL FEVKENTNLS GPLVTVDVPQ GQQVTLAASS
TPFAFRIQGN QLFLNVTPDY EENALLQADL ECKRGDTVVT QLRVWVSVLD VNDNPPTFPF
VVRVKRVPED TKVNTTVIPA TELQAQDLDK DDILFYSLQE VTPGASAFFS LVGANLPALQ
LDRTLDLDRW PNMTFQLLVR DTREENVNPS HTATATLVLE VQPVDLRPPW FLPCAYRDSY
VCIQAQYHGA VPTGYQLPTP LILDPGPIYA VDGDAAINQR ITYSIIGGHE DTFTIDTNSG
NLTMTRSVDS PKTFLLWVKG EQEDQARYSV TQVTVEARDA IGSLPRFPES LYRGTVALGA
EVGEAVKDAA APSQSLRIRA QDPDFPDLNS AITYGITNNS NFRMAGETVQ VAKPLVYTGV
FYAEVEAKNT VTAGTATTVV EIRVSEQETI PTGTPGAGGG SATGDGEPGH TGDRNFSTAE
MAAVGGVLGA LLLLALIALT VLIYKHYGHR CKCCAGKALE PQPGGFDNKA FLTHDGEANW
APAPSPEPCP TSDEAPPEPL EPTPLEPAPP APPSLVPPAC VPESPMAAQD GGSPAEVRSI
LTKERRPEGG YKAVWFGEDI GAEADVVVLN VPTSDADGAG DWDSQGGGAA EGAPSDGPSD
STND
//
