ID F6ZC00_HORSE Unreviewed; 205 AA.
AC F6ZC00;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Zinc finger and SCAN domain containing 16 {ECO:0000313|Ensembl:ENSECAP00000007846.2};
GN Name=ZSCAN16 {ECO:0000313|Ensembl:ENSECAP00000007846.2,
GN ECO:0000313|VGNC:VGNC:25413};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007846.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000007846.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007846.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000007846.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007846.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; F6ZC00; -.
DR STRING; 9796.ENSECAP00000007846; -.
DR PaxDb; 9796-ENSECAP00000007846; -.
DR Ensembl; ENSECAT00000010197.4; ENSECAP00000007846.2; ENSECAG00000009944.4.
DR CTD; 80345; -.
DR VGNC; VGNC:25413; ZSCAN16.
DR GeneTree; ENSGT00940000163165; -.
DR HOGENOM; CLU_002678_49_3_1; -.
DR InParanoid; F6ZC00; -.
DR OMA; QKCSPHR; -.
DR OrthoDB; 4330481at2759; -.
DR TreeFam; TF338304; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000009944; Expressed in blood and 24 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR PANTHER; PTHR45935:SF15; SCAN DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02023; SCAN; 1.
DR SMART; SM00431; SCAN; 1.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 41..123
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT REGION 154..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 205 AA; 23771 MW; AAA28E11950C220F CRC64;
MATALEPEEQ KGLLIVKAED PYWGQHSISQ KYSPHRRELF RQHFRKLCYQ DAPGPREALT
RLQELCRQWL RPEYHTKEQI LDLLVLEQFL SILPRELQAW VQAHHPETGE EAVTVLEDLE
RELDEPRKQV PANSERQDTL LDKLAPLGRP HESLTVQLHP KKTQQEQESG APQRNVLEPG
KYKIKGANRP QESQPAVTPV CKRSC
//
