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Database: UniProt
Entry: F6ZCW7_MONDO
LinkDB: F6ZCW7_MONDO
Original site: F6ZCW7_MONDO 
ID   F6ZCW7_MONDO            Unreviewed;      2698 AA.
AC   F6ZCW7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSMODP00000020725};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSMODP00000020725};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000020725, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000020725, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000020725}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   RefSeq; XP_001363102.1; XM_001363065.3.
DR   STRING; 13616.ENSMODP00000020725; -.
DR   Ensembl; ENSMODT00000021092; ENSMODP00000020725; ENSMODG00000016591.
DR   GeneID; 100010212; -.
DR   KEGG; mdo:100010212; -.
DR   CTD; 3709; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; F6ZCW7; -.
DR   KO; K04959; -.
DR   OMA; ENQVKGG; -.
DR   OrthoDB; 94996at2759; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000002280; Chromosome 8.
DR   Bgee; ENSMODG00000016591; Expressed in 8 organ(s), highest expression level in liver.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2225   2247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2259   2278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2299   2323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2343   2371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2392   2414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2519   2542       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED     1920   1940       {ECO:0000256|SAM:Coils}.
FT   COILED     2629   2677       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2698 AA;  307957 MW;  28F3B73D17848713 CRC64;
     MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDVAGNEGSW FYIHPFWKLR SEGDNIVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKYSCYR EDVLKGGDVV
     RLFHAEQEKF LTCDEYEKIQ YIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
     SLFRFKHLAT GNYLAAELNP DYRDANNEGK VVRDGDLPTS KKKRQAGEKI MYTLVSVPHG
     NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TSIPIDTDEE RPVMLKIGTC
     QTKEDKEAFA IVSVPLSEVR DLDFANDANK VLASTVKKME HGAITQNERR FVTKLLEDLI
     FFVADVPNNG QDVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKDRG GEGSMLRLED
     LGDQRYAPYK YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TAKEIETFVN LLRRNREPRF LDYLSDLCVS NTTAIPVTQE LICKFMLSPG
     NADILIQTKL VSMQIDNPLE CSILSDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAKEGT
     KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCMSDESL PYDLRASFCR
     LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIYEYDSIT DSSRNDMKRK FALTMEFVEE
     YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQGPM
     SSYLERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVQPNT HAIKQASTID
     NEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF GDNNENPENS TTTPPDTPLS
     SAIVPDIDEI AAQAETMFAG RKEKNPVQLD DEGGRTFLRV LIHLIMHDYP PLLSGALQLL
     FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSSYENGE
     MSESQVKGGE EPNEESNILS PVQDGTKKPQ IDSNKSNNYK IVKEILIRLS KLCVQNKKCR
     NQHQRLLKNM GAHSVVLDLL QIPYEKSDEK MNEVMNLAHT FLQNFCRGNP QNQVLLHKHL
     NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD
     GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLQMMC SERDRGDDSG PLAYHVTLVE
     LLAACTEGKN VYTEIKCNSL LPLDDIVRVV AHDDCIPEVK IAYVNFVNHC YVDTEVEMKE
     IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADIFLEKCVT EPIMNIVSGF FNSPFSDNST
     SLQTHQPVFI QLLQSAFRIY NCTWLNPIQK ASVESCIKTL AEVAKNRGIA IPVDLDSQVN
     TLFMKSHSNM VQRAAMGWRM SARSGPRFKE ALGGPAWDYR NIIEKLQDVV GSLEQQFSPM
     MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE
     MLEKKDSFVE EGSTLRKILL NRYFKGDYGT GVNGHLSGTY SKTGQGNFSG QDSDKMGISV
     SDIQCLLDKE GASELVIDVI VNTKNDKIFS EGILLGIALL EGGNTQTQYS SYQQLHEQKK
     SEKFFKVLYD HMKAAQKEIR STVTVNTIDL GSKKKDDDND LIATSPRMRV RDPSLHLKEG
     MKGQLTEASS ATSKAYCVYR REMDPEIDIM CTGTDAGNTD EKSADEVTMS PTIAIMQPIL
     RFLQLLCENH NRELQNFLRN QNNKTNYNLV CETLQFLDCI CGSTTGGLGL LGLYINERNV
     ALVNQTLESL TEYCQGPCHE NQTCIATHES NGIDIIIALI LNDINPLGKY RMDLVLQLKN
     NASKLLLAIM ESRHDSENAE RILFNMRPRE LVDVMKNAYN QGVECDHEDD RGDDSISPKD
     VGHNIYILAH QLARHNKALQ QMLKPGSDPE EGDEALKYYA NHTAQIEIVR HDRTMEQIVF
     PVPNICEYLT RESKSRVFNT TERDEQGSKV NDFFQQTEDL YNEMKWQKKI RNNPALFWFS
     RHISLWGSIS FNLAVFINLA VALFYPFGDD GDEGTLSPLF SVLLWIAVAV CTSMLFFFPK
     PFGIRPFLVS IMLRSIYTIG LGPTLILLGA ANLCNKIVFL VSFVGNRGTF TRGYRAVIMD
     MAFLYHVAYV LVCMLGLFVH EFFYSFLLFD LVYREETLLN VIKSVTRNGR SIILTAVLAL
     ILVYLFSIIG FLFLKDDFTM EVDRLKNRTP ITGSNEVHTM TLTSIMGACT KENCSPTIPI
     SNTVEEDDED GIERTCDTLL MCIVTVLNQG LRNGGGVGDV LRKPSKDEPL FAARVVYDLL
     FYFIVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVSFEEHI
     KSEHNMWHYL YFIVLVKVKD PTEYTGPESY VAQMIAEKNL DWFPRMRAMS LVSNESDSEQ
     NEIRNLQEKL ESTMSLVKQL SGQLAELKEQ MTEQRKNKQR LGFLGSNTPH VNHHMPLH
//
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