ID F6ZE23_MACMU Unreviewed; 994 AA.
AC F6ZE23;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=TOG array regulator of axonemal microtubules 2 {ECO:0000313|Ensembl:ENSMMUP00000005780.4};
GN Name=TOGARAM2 {ECO:0000313|Ensembl:ENSMMUP00000005780.4,
GN ECO:0000313|VGNC:VGNC:106241};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000005780.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000005780.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000005780.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6ZE23; -.
DR PaxDb; 9544-ENSMMUP00000005780; -.
DR Ensembl; ENSMMUT00000006139.4; ENSMMUP00000005780.4; ENSMMUG00000004324.4.
DR VEuPathDB; HostDB:ENSMMUG00000004324; -.
DR VGNC; VGNC:106241; TOGARAM2.
DR eggNOG; KOG2933; Eukaryota.
DR GeneTree; ENSGT00940000156217; -.
DR HOGENOM; CLU_025226_0_0_1; -.
DR InParanoid; F6ZE23; -.
DR OMA; TPSKGWQ; -.
DR OrthoDB; 3679265at2759; -.
DR Proteomes; UP000006718; Chromosome 13.
DR Bgee; ENSMMUG00000004324; Expressed in olfactory segment of nasal mucosa and 5 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF42; TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 2; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 481..716
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 756..992
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 22..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 108362 MW; AE2D586D5274B47C CRC64;
MGTRDDFPKA KVLAPVAEYC GSIPRTSAGP RVLPPGSINS SLPHGEGSLQ PEPSTLLSNE
EPSQLPSGHG ELGGRKLDTP SKGWQERNGC PRNLGALSLG AQPLVLLPSL ESEANSVARD
TTQIKDKLKK RRLSEGLAAS SRASLNPGGG PQGVPLWSTI PRATSQRLLR VPRPMPPIQS
IPTTPEASGV KEKGLDLPGN VPGPHELRPG AQEAQISRQY LHCNDEKIQK SLGGIVIPPI
PKARPVAAAP SCVPGSLPSP LPPGQGVLTG LRAPHLRLAR ESGPREKTPA SVEPKPLASP
IRDRPAAAKK PALPFSQSAP TLTAFSFDHA KEACPLLKEE DRKEINTKIQ VTISKSAQEK
MRLKQMKEME LLRRPEEPRT ERKLTPQGLG SRRAFMKEGL LPLRGSGTLS VPTRLSGPRR
NDVSVILRKQ ASRTSLPSIP VSQQEPRFVR HASANSLPAV LTLGSPEWEE EEEMDLRGCK
ELRPFSNPEL GLMDALQCLN SSDWQMKQKG LVSIQRLAAC HSEVLTGRLH DVCLAVTGEV
TNLRSKVSCL AITTLGDLFQ ALKKNMDQEA EEIARCLLQK MGDTSEFIRR AAGQSLRAMV
ENVTLARSLV VLTSAGVYHR SPLVRKYAAE HLSAVLEQIG AEKLLSGSRD STDMLVRNLV
RLAQDSNQDT RFYGRKMVNI LMANTKFDAF LKQSLPPYDL KKVMAAIKQR GIEDNDELPS
AKGLKVSRSL VVCENGLPIK EGFSSNGPRL VGLRSMLQGS GEMVEQLREL MRLLEAKDFR
SRMEGVGRLL DFCKAKPELV AAHLVQVFDA FTPRLQDSNK KVSQWALESL AKMIPLLKEN
LHPMLLSIII AVAENLNSKN SGIYAAAVAV LDAMVESLDN LCLLPAFAGR VRFLSGRAVL
DVTDRLAVLV ASVYPRKPQA VERHVLPILW HFLNTTTGKG TLPGPSGNIR GVVSRLARSL
QEHMGPRLLD FAASQPKHVL KMLQELLRLG VLGR
//
