ID F6ZEJ1_ORNAN Unreviewed; 2042 AA.
AC F6ZEJ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSOANP00000020295.3};
GN Name=DOCK11 {ECO:0000313|Ensembl:ENSOANP00000020295.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000020295.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000020295.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020295.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000020295.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020295.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9258.ENSOANP00000020295; -.
DR Ensembl; ENSOANT00000020298.3; ENSOANP00000020295.3; ENSOANG00000012828.4.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155658; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR InParanoid; F6ZEJ1; -.
DR OMA; YDHYIPL; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000002279; Chromosome 6.
DR Bgee; ENSOANG00000012828; Expressed in endometrium and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 131..238
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 607..785
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1577..2004
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 247..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2042 AA; 233956 MW; 99F4A7EA0EDB12EA CRC64;
EKTKVVEPLD YENVITQRKA QIYSDPLRDL LMFPMEDVSV SVICRQRRTV QSTVPEDAEK
KAQSLFVKEC IKTYSSDWQV VNYKYEDFSS DFRMLPCKSL RPEKIPSHVF EVDEDFEKDE
DSSSLCSQKG GVIKQGWLHK ANVNSTITVT MKVFKRRYFY LTQLPDGSYI LNSYKDEKNS
KESKGCIYLD ACIEVVQCPK MRRHAFELKM LDKYSHYLAA ETEQEMEEWL TTLKKIIQIN
TDSLVQEKKD PAESVQDDET SSQGKPENIM ESLERSMHPE LMKYGRETEQ LNKLSRGDGR
QNLFSFDSDV QRLFFSGIES EIKPFEEKCS RRFMVKCHDL SFNILGHVGD QTGGPLTNVE
PFFVSLALFD VKNNCKISAD FHVDLNPSSV REMLLGTSVQ LPNDGNLKGS SPNECSFHGI
AESHLRCIKQ GIFSVTNPHV EIFLVARVEK VLQGSITHCA EPYIKNSDPV KVAQKVHKTA
RLVCSRLGQY RMPFAWAARP VFKDTQGSLD LDGRFSPLYK QDSSKLSSDD ILKFLAEYRK
PEKTKLQIIP GQLNITLDSV AVDFSNCVTA SYVPVKPFEK NCQDITVEVE EFVPDVAKYC
YPFTIYKNHL YVYPLQLKYD SQKTFAKARN IAVCMEFRDS DDSDASALKC IYGKPAGSIF
TTHVYAIVSH HNQNPEFYDE IKIELPIHLH QKHHLLFTFY HVSCEINTKG TTKKQDMVET
PVGFAWVPLL KDGRIITFEQ QLPVSANLPH GYLGFNELES RRQPSVDIKW VDGAKPLLKI
RSHLESTIYT QDLHLHKFFH HCQMIQAGSK EVPGELIKYL KCLHAMEIQV MIQFLPVILM
QLFRVLTNMT QDDEVAVNCT MVLLHIVSKC HEEGLDHYLR SFIKYGFRAE KPNAAQAKMT
HEILAIAMTS ILKLSADFLS INKLLKYSWF FFEALAKSMA TYLLEENKIK LPRAQRFPES
YHHVLHSLLL AIIPHVTIRY GEIPDESRNV NFSLANFLKR CLTFMDRGFI FNLINDYVSG
FSPKDPKVLS EYKFEFLQTV CNHEHYIPLN LPMPFAKPKL QRVQDSNLEY SLSDEYCKNH
FLVGLLLREA SVALQDNYDI RSTAISVLKN LFIKHAFDTR YQHKNQQAKI AQLYLPLVGV
LLENTQRLAG RETTYSCTAV SNSASRDEFV CGFTSPSNRA SLIGDKDTVY GSSFPNGHGL
KREDSRGSMS TEGAASSPDQ CSTGENTRRS STRSSVSQYN RLDQYEIRSL LMCYLYIVKM
ISEDTLLTYW NKVSPQELIN ILTLLEVCLF HFRYVGKRNI ARIHDAWLTK HFGVDRKSQT
MPALRSRSGM MQARLQHLSS LESSFTLNHN SGTSEADIVH QALLEGNTAT EVSLTVLDTI
SFFTQCFKNQ LLNNDGHNPL MKKVFDIHLA FLKNGQSEAS LKHVFASLRA FISKFPAAFF
KGRVNMCAAF CYEVLKCCTS KLSSTRNEAS ALLYLLMRNN FEFTKRKTFL RTHLQIIIAV
SQLIADVALS GGSRFQESLS IINNFANSDR PMKATAFPSE VKDLTKRIRT VLMATAQMKE
HERDPEMLID LQYSLAKSYA STPELRKTWL DSMAKIHIKN GDFSEAAMCY VHVAALVAEF
LHRKKLFSSG CSAFKKVTPN IDEEGAMKED AGMMDVHYSE EVLLELLEQC VDGLWKAERY
EVISEISKLI IPIYEKRREF EKLTQVYRTL HGAYTKVLEV MHTRKRLLGT FFRVAFYGQS
FFEEEDGKEY IYKEPKLTGL SEISLRLLKL YGEKFGADSV KIIQDSDKVN VKDLDPKYAH
IQITFVKPYF EDKELSERKT DFEKNHNINR FVFEAPYTLS GKKHGCIEEQ CKRRTILTTA
NTFPYVKKRI PVNQEQQIHL KPIDVATDEI KDKTAELQML CSSPEVDMIQ LQLKLQGCVS
VQVNAGPLAY ARAFLNDNQL SKYPSKKVNE LKEMFRKFIQ VCSIALELNE RLIKEDQIEY
HEGLKSNFRD MVKELSDIIH EQMFQEDTMQ SPWMHDTLHV FCAISGISGD GGYGSPRHAA
EV
//