ID F6ZFT3_MACMU Unreviewed; 250 AA.
AC F6ZFT3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Charged multivesicular body protein 3 {ECO:0000256|ARBA:ARBA00041079};
DE AltName: Full=Chromatin-modifying protein 3 {ECO:0000256|ARBA:ARBA00041641};
DE AltName: Full=Vacuolar protein sorting-associated protein 24 {ECO:0000256|ARBA:ARBA00042517};
GN Name=RNF103 {ECO:0000313|Ensembl:ENSMMUP00000017251.3};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017251.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000017251.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017251.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the SNF7 family.
CC {ECO:0000256|ARBA:ARBA00006190}.
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DR AlphaFoldDB; F6ZFT3; -.
DR SMR; F6ZFT3; -.
DR PaxDb; 9544-ENSMMUP00000017251; -.
DR Ensembl; ENSMMUT00000018424.4; ENSMMUP00000017251.3; ENSMMUG00000015778.4.
DR VEuPathDB; HostDB:ENSMMUG00000015778; -.
DR GeneTree; ENSGT00390000006413; -.
DR HOGENOM; CLU_069208_0_1_1; -.
DR OMA; INEMMDD; -.
DR TreeFam; TF105848; -.
DR Proteomes; UP000006718; Chromosome 13.
DR Bgee; ENSMMUG00000015778; Expressed in adipose tissue and 22 other cell types or tissues.
DR ExpressionAtlas; F6ZFT3; baseline.
DR GO; GO:1904930; C:amphisome membrane; IEA:UniProt.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:UniProt.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProt.
DR GO; GO:0030496; C:midbody; IEA:UniProt.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProt.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProt.
DR GO; GO:0097352; P:autophagosome maturation; IEA:UniProt.
DR GO; GO:1902774; P:late endosome to lysosome transport; IEA:UniProt.
DR GO; GO:0061952; P:midbody abscission; IEA:UniProt.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:UniProt.
DR GO; GO:0071985; P:multivesicular body sorting pathway; IEA:UniProt.
DR GO; GO:0031468; P:nuclear membrane reassembly; IEA:UniProt.
DR GO; GO:0001778; P:plasma membrane repair; IEA:UniProt.
DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:UniProt.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:UniProt.
DR GO; GO:0046761; P:viral budding from plasma membrane; IEA:UniProt.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProt.
DR Gene3D; 6.10.140.1230; -; 1.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR10476; CHARGED MULTIVESICULAR BODY PROTEIN; 1.
DR PANTHER; PTHR10476:SF1; CHARGED MULTIVESICULAR BODY PROTEIN 3; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT REGION 208..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 250 AA; 28175 MW; 0FE7C1EF8AB4E751 CRC64;
MEGELYSALK EEASESVSST NFSGEMHFYE LVEDTKDGIW LVQVNEWSLK IRKEMRVVDR
QIRDIQREEE KVKRSVKDAA KKGQKDVCVV LAKEMIRSRK AVSKLYASKA HMNSVLMGMK
NQLAVLRVAG SLQKSTEVMK AMQSLVKIPE IQATMRELSK EMMKAGIIEE MLEDTFESMD
DQEEMEEAAE MEIDRILFEI TAGALGKAPS KVTDALPEPE PSGAMAASDE EEEEEEALEA
MQSRLATLRS
//
