ID F6ZFV0_MOUSE Unreviewed; 189 AA.
AC F6ZFV0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Serine (or cysteine) peptidase inhibitor, clade B, member 2 {ECO:0000313|Ensembl:ENSMUSP00000114751.2};
DE Flags: Fragment;
GN Name=Serpinb2 {ECO:0000313|Ensembl:ENSMUSP00000114751.2,
GN ECO:0000313|MGI:MGI:97609};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114751.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000114751.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114751.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000114751.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114751.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR MaxQB; F6ZFV0; -.
DR PeptideAtlas; F6ZFV0; -.
DR ProteomicsDB; 324287; -.
DR Antibodypedia; 1909; 540 antibodies from 34 providers.
DR Ensembl; ENSMUST00000143832.8; ENSMUSP00000114751.2; ENSMUSG00000062345.11.
DR AGR; MGI:97609; -.
DR MGI; MGI:97609; Serpinb2.
DR VEuPathDB; HostDB:ENSMUSG00000062345; -.
DR GeneTree; ENSGT00940000161637; -.
DR HOGENOM; CLU_023330_2_0_1; -.
DR ChiTaRS; Serpinb2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000062345; Expressed in skin of external ear and 63 other cell types or tissues.
DR ExpressionAtlas; F6ZFV0; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF61; PLASMINOGEN ACTIVATOR INHIBITOR 2; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:F6ZFV0,
KW ECO:0007829|MaxQB:F6ZFV0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..189
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000114751.2"
SQ SEQUENCE 189 AA; 21724 MW; 48D45F824A4795E4 CRC64;
XSANKLFGEK SARFKEEYIQ LSKKYYSTEP EAVDFLECAE EAREKINSWV KTQTKGEIPN
LLPEGSVDED TKMVLVNAVY FKGKWKTPFE KKLNGLYPFR VNSHESIPVQ MMFLHAKLNI
GYIKDLKTQI LELPHTGNIS MLLLLPDEIE DASTGLELLE SEINFANFNK WISKDTLDED
DVVVAQWPH
//
