ID F6ZHN9_CALJA Unreviewed; 809 AA.
AC F6ZHN9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Endothelial PAS domain protein 1 {ECO:0000313|Ensembl:ENSCJAP00000001230.4};
GN Name=EPAS1 {ECO:0000313|Ensembl:ENSCJAP00000001230.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000001230.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000001230.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000001230.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
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DR AlphaFoldDB; F6ZHN9; -.
DR Ensembl; ENSCJAT00000001305.5; ENSCJAP00000001230.4; ENSCJAG00000000700.5.
DR eggNOG; KOG3558; Eukaryota.
DR GeneTree; ENSGT00940000155930; -.
DR HOGENOM; CLU_010044_3_1_1; -.
DR TreeFam; TF317772; -.
DR Proteomes; UP000008225; Chromosome 14.
DR Bgee; ENSCJAG00000000700; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001666; P:response to hypoxia; IEA:UniProt.
DR CDD; cd19728; bHLH-PAS_HIF2a_PASD2; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 14..67
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 92..147
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 249..300
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 405
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 528
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 786
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 809 AA; 89772 MW; F6258ED21D93A1D9 CRC64;
MTADKEKKRS TSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA
ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG
LTQVELTGHS IFDFTHPCDH EEIRENLSLK NGSGFGKKSK DMSTERDFFM RMKCTVTNRG
RTVNLKSATW KVLHCTGQVK VYNNCPPHSS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD
SKTFLSRHSM DMKFTYCDDR ITELIGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG
QVVSGQYRML AKHGGYVWLE TQGTVIYNPR NLQPQCIMCV NYVLSEIEKN DVVFSMDQTE
SLFKPHLIAM NSIFDSSGKG AVSEKSNFLF TKLKEEPEEL AQLAPTPGDA IISLDFGNQN
FEESSTYGKA ILPPSQPWAT ELRSTQSEAG SLPAFTVPQA AATGSTTPSA TSSSSCSTPN
SPEDYYTSLD NDLKIEVIEK LFAMDTEAKD QCSTQTDFNE LDLETLAPYI PMDGEDFQLS
PICPEERLLP ENPQSTPQNC FSAMTNIFQP LAPVASHSPF LLDKFQQQLE SKKTEPEHRP
MSSIFFDAGS KASLPPCCGQ ASTPLSSMGG RSNTQWPPDP PLHFGPMKWA VGDQHTEFLG
AATLGPPVSP PHVSTFKTRS AKGFGARGPD MLSPAMVALS NKLKLKRQLE YEEQAFQDLS
GGDPPGGNTS HLMWKRMKNL RGGSCPLMPD KPLSANVPNG MASRLLGPSF ESYLLPELTR
YDCEVNVPVL GSSTLLQGGD LLRALDQAT
//