ID F6ZP20_MACMU Unreviewed; 325 AA.
AC F6ZP20; F7ED08;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Lipid droplet-associated hydrolase {ECO:0000256|ARBA:ARBA00019242};
DE AltName: Full=Lipid droplet-associated serine hydrolase {ECO:0000256|ARBA:ARBA00031924};
GN Name=LDAH {ECO:0000313|Ensembl:ENSMMUP00000036719.1,
GN ECO:0000313|VGNC:VGNC:74130};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000036719.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000036719.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000036719.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. LDAH family.
CC {ECO:0000256|ARBA:ARBA00008300}.
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DR RefSeq; XP_014967258.1; XM_015111772.1.
DR RefSeq; XP_014967259.1; XM_015111773.1.
DR STRING; 9544.ENSMMUP00000004469; -.
DR PaxDb; 9544-ENSMMUP00000004469; -.
DR Ensembl; ENSMMUT00000004741.4; ENSMMUP00000004469.4; ENSMMUG00000003355.4.
DR Ensembl; ENSMMUT00000043729.3; ENSMMUP00000036719.1; ENSMMUG00000003355.4.
DR GeneID; 717510; -.
DR CTD; 60526; -.
DR VEuPathDB; HostDB:ENSMMUG00000003355; -.
DR VGNC; VGNC:74130; LDAH.
DR eggNOG; KOG3975; Eukaryota.
DR GeneTree; ENSGT00390000009688; -.
DR HOGENOM; CLU_018394_2_1_1; -.
DR OMA; WVPVSYY; -.
DR OrthoDB; 5474978at2759; -.
DR TreeFam; TF313050; -.
DR Proteomes; UP000006718; Chromosome 13.
DR Bgee; ENSMMUG00000003355; Expressed in adipose tissue and 21 other cell types or tissues.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0019915; P:lipid storage; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR019363; LDAH.
DR PANTHER; PTHR13390; LIPASE; 1.
DR PANTHER; PTHR13390:SF0; LIPID DROPLET-ASSOCIATED HYDROLASE; 1.
DR Pfam; PF10230; LIDHydrolase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
SQ SEQUENCE 325 AA; 37408 MW; F70C6CEAE5143B7A CRC64;
MDSELKEEIP VHEEFILCGG VETQVLKCGP WTDLFNDQSV KRPKLLIFII PGNPGFSAFY
VPFAKALYSL TNRRFPVWTI SHAGHVLAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELLVIRA FLLFPTIERM SESPNGRIAT
PLLCWFRYVL YVTGYLLLKP CPEKIKSLLI RRCLQLMNLE NEFSPLNVLE PFCLANAAYL
GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
AFITHFNQEV ANMIADSLKD DLSKM
//
