ID F6ZPV8_CIOIN Unreviewed; 417 AA.
AC F6ZPV8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN Name=LOC100181032 {ECO:0000313|Ensembl:ENSCINP00000004526.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000004526.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000004526.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; EAAA01002649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6ZPV8; -.
DR STRING; 7719.ENSCINP00000004526; -.
DR Ensembl; ENSCINT00000004526.3; ENSCINP00000004526.3; ENSCING00000002211.3.
DR GeneTree; ENSGT00940000156729; -.
DR HOGENOM; CLU_010194_25_0_1; -.
DR InParanoid; F6ZPV8; -.
DR OMA; WWSSVAN; -.
DR TreeFam; TF101523; -.
DR Proteomes; UP000008144; Chromosome 8.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd09762; HSDL2_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 318..409
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 417 AA; 45117 MW; 73B5CB2BB901A6B0 CRC64;
LIKYPHKLAG YTLFITGASR GIGKAIGLRA ARDGANVVIA AKTAEAHPKL PGTIYTAAKE
IEDAGGKCLP CIVDVRDEAM VEKAVKEAVS TFGGIDILVN NASAISLTGT EVTKMKTYDL
MNQVNTRGTY LCSKVCVPHL LDSKKRGKSP HILNISPPLS MKPMWFKNHT AYTIAKYGMS
MCVLGMAAEF EESGIAVNAL WPKTAILTAA MEMLGGKDVS SQCRKPEIMA DAAYAILKQE
TLSTGKFFID DEVLAKEGVT DFDQYAVEPG KPLILDFFLE DNEADFKGQE ADFQGQIEKA
KAASKGGEIV GIFNNIKNAL STELVAQTKG VFKFEIKDGD AVETWVLDLK NGEGKVTKGD
GDSDVVMKMA SSDFVSMFQG KLNSTAAFMQ GKLKIDGNMI LPMKLEHLMT KMQKAKL
//