ID F6ZUG7_ORNAN Unreviewed; 666 AA.
AC F6ZUG7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Autophagy related 7 {ECO:0000313|Ensembl:ENSOANP00000003463.3};
GN Name=ATG7 {ECO:0000313|Ensembl:ENSOANP00000003463.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003463.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000003463.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003463.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000003463.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003463.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6ZUG7; -.
DR STRING; 9258.ENSOANP00000003463; -.
DR Ensembl; ENSOANT00000003464.3; ENSOANP00000003463.3; ENSOANG00000002182.3.
DR eggNOG; KOG2337; Eukaryota.
DR GeneTree; ENSGT00390000017509; -.
DR HOGENOM; CLU_012998_2_1_1; -.
DR TreeFam; TF105689; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000002182; Expressed in endometrium and 8 other cell types or tissues.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR InterPro; IPR032197; Atg7_N.
DR InterPro; IPR042522; Atg7_N_1.
DR InterPro; IPR042523; Atg7_N_2.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR Pfam; PF16420; ATG7_N; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 19..329
FT /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16420"
FT DOMAIN 345..436
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 666 AA; 73536 MW; F38110EFA854A424 CRC64;
MATAPGDVPL PSESGFSKLQ FAPFSSALDA GFWHELTQKK LNEYRLDETP KDIKGYYYNG
DSAGLPARLT LEFSAFDVNA ATPARCCPAI GTLYNTNTLE SFKTCDKKLL LEKAANEIWE
SIKSGAALEN PVLLNKFLLL TFSDLKKYHF YYWFCYPALC LPEGVPLIRQ PLGLGQRFSP
SQIQALECAY DDLCQAEGVT ALPYFLIKQD GNSVLASSLK NWKAFFQDQR KKVTVGVYDP
CNLAHYPGWP LRNLLVLAAH KWSSHFQTVE VLCFRDRTMQ GVRDITHSII FEVKLPQMAF
SPDCPKAVGW EKNQKGSMGP RMVNLSECMD PKRLAESSVD LNLKLMCWRL VPTLDLEKVV
SVKCLLLGAG TLGCSVARTL MGWGVRHITF VDNAKISYSN PVRQPLYEFE DCLGGGKPKA
LAAANRLQKI FPGVLVINAA LGFDTFVVMR HGLKKPKEQS IGNEGLTQPS GSADLLGSSL
FSNIPGYKLG CYFCNDVVAP GDSTRDRTLD QQCTVSRPGL AMIAGALAVE LMVSVLQHPE
GGYAVASSSD DRMNEPPTSL GLVPHQIRGF LSRFDNVLPV SLAFDKCTAC SSKILDQYER
EGFHFLAKVF NSSHSFLEDL TGLTLLHQET QAAEVPEKRG VKSAWLVASG PESRDDIWDM
SDDETV
//
