ID F6ZUZ2_CIOIN Unreviewed; 557 AA.
AC F6ZUZ2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Polynucleotide 5'-hydroxyl-kinase NOL9-like {ECO:0000313|Ensembl:ENSCINP00000021870.2};
GN Name=LOC100179576 {ECO:0000313|Ensembl:ENSCINP00000021870.2};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000021870.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000021870.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00011003}.
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DR EMBL; EAAA01001467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6ZUZ2; -.
DR STRING; 7719.ENSCINP00000021870; -.
DR Ensembl; ENSCINT00000022116.2; ENSCINP00000021870.2; ENSCING00000011450.2.
DR GeneTree; ENSGT00940000153668; -.
DR HOGENOM; CLU_489105_0_0_1; -.
DR InParanoid; F6ZUZ2; -.
DR TreeFam; TF313802; -.
DR Proteomes; UP000008144; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 282..427
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 62587 MW; 2199D3F3729C37C6 CRC64;
MAGAKKSTSK KDLKTKLSNK IRKTTKKMKD SKLCKSMKSK RMKLKEEIST ENKETKEEIT
FCSSSCDNSQ SQEDELMPSP YKKYKLEQMS RMLESVNICP LLPDDCELFP IKKNNESALL
AMKSTSSGVK LHGCAKVSVI CGLCVINGFT LSVENSPQVI MAPLTHVATT VRPIAVETKQ
CRKDIYKKYK TAVSNIKDTL DKYEVILLFQ STSIQTLSYP GYPDIFTPSI TEVKDFRVLC
KQCFLCSTSR YFIEHNSYTE AVNSLRSHDN NTQSYPVIVT AGGKNVGKST FNRYLVNRLL
SDHKHVYYLD CDIGQSEFTP SGFISVTRIE QNQPLLSPTF TNEVKPMLMC YYGHNTPSGD
PDFYSSCVQF VLQSLFEVLN GNLDGPLVVN TMGWIRALGL QLLIDTIRMV NPTHIMQFQT
AKDSRNLAPM TKEFVSSMTG WLTPQSHACH ELVTIATSIT PLEIIKYMAP DYRNLAMLSK
LSQIADACVN RDSSINQKLT RQTLLGKLQS AQPFKISLKH LQVYNATDSQ VKYKHVLAAL
NASVVALCIS PESKQDW
//
