ID F6ZVI6_ORNAN Unreviewed; 430 AA.
AC F6ZVI6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Tektin {ECO:0000256|RuleBase:RU367040};
GN Name=TEKT2 {ECO:0000313|Ensembl:ENSOANP00000003290.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000003290.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000003290.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000003290.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. Required for normal sperm mobility.
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|RuleBase:RU367040}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton,
CC microtubule organizing center {ECO:0000256|ARBA:ARBA00004267}.
CC -!- SIMILARITY: Belongs to the tektin family.
CC {ECO:0000256|ARBA:ARBA00007209, ECO:0000256|RuleBase:RU367040}.
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DR AlphaFoldDB; F6ZVI6; -.
DR STRING; 9258.ENSOANP00000003290; -.
DR Ensembl; ENSOANT00000003291.3; ENSOANP00000003290.2; ENSOANG00000002075.3.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_0_0_1; -.
DR InParanoid; F6ZVI6; -.
DR OMA; FDHRGKM; -.
DR TreeFam; TF320754; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000002075; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0005879; C:axonemal microtubule; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:UniProtKB-UniRule.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR InterPro; IPR048256; Tektin-like.
DR InterPro; IPR000435; Tektins.
DR PANTHER; PTHR19960; TEKTIN; 1.
DR PANTHER; PTHR19960:SF7; TEKTIN-2; 1.
DR Pfam; PF03148; Tektin; 1.
DR PRINTS; PR00511; TEKTIN.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|RuleBase:RU367040};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367040};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|RuleBase:RU367040};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT COILED 269..362
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 430 AA; 49969 MW; 01945473D1C5D861 CRC64;
VTMLSVKPGP RFTVPDWQTS NFLLSSNAER QRDAAYQIRQ EARTLRNETN SQTKWDEHDN
RTRLEERMES IKRWKEALDK CLAEIDAEID ALSKVKEAAE RALQAKGLPL DVAIECLTLR
ESRRDIDVVK DSVEDELHKE VELIDGIKKT LQGRIDEAFE QLCLLQEARQ QLNFDHRNKM
EALEIDRVCH SLNVNSPNIS LKVNPTRVPT GSTTPQQWDE FSQYNKDRAE AEIKASMELR
EAIALTIAGT DNELEAQRVM AEFAFRKRMR EMEKAYDELR WQEKNILEEI SGMEEDIRRL
EEDLRRKMDN LKLAHTRLET RTYRPNVDLC RDQVQYGLTD EVHQLEGTVA VLKQKLAQSK
DALDALYKHL ARVQADIICK ANSLQLDNKC MDTRRKLTVP AEKYVPEMDT FNRTTNRTLP
PVKSYQLELA
//
