ID F6ZW73_MACMU Unreviewed; 3093 AA.
AC F6ZW73;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Bromodomain PHD finger transcription factor {ECO:0000313|Ensembl:ENSMMUP00000012743.4};
GN Name=BPTF {ECO:0000313|Ensembl:ENSMMUP00000012743.4,
GN ECO:0000313|VGNC:VGNC:70464};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000012743.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000012743.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012743.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F6ZW73; -.
DR Ensembl; ENSMMUT00000013601.4; ENSMMUP00000012743.4; ENSMMUG00000009734.4.
DR VEuPathDB; HostDB:ENSMMUG00000009734; -.
DR VGNC; VGNC:70464; BPTF.
DR eggNOG; KOG1473; Eukaryota.
DR eggNOG; KOG1632; Eukaryota.
DR eggNOG; KOG1827; Eukaryota.
DR GeneTree; ENSGT00940000154830; -.
DR HOGENOM; CLU_000284_1_0_1; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000009734; Expressed in Ammon's horn and 22 other cell types or tissues.
DR ExpressionAtlas; F6ZW73; baseline.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 239..299
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 389..436
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2856..2907
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2914..2965
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2991..3061
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1908..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2150..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2222..2259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2703..2722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2785..2847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1958..1985
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2609..2639
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1088
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2335..2395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2402..2538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2703..2719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2786..2810
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2823..2847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3093 AA; 343199 MW; F72A7E936FB4C2A9 CRC64;
MRGRRGRPPK QPAAPAAERC APAPPPPPPP PTSGPIGGLR SRHRGSSRGR WAAAQAEVAP
KTRLSSPRGG SSSRRKPPPP PAPPSTSAPG RGGRGGGGGR TGGGGGGGHL ARTTAARRAV
NKVVYDDHES EEEEEEEDMV SEEEEEEDGD AEETQDSEDD EEDEMEEDDD DSDYPEEMED
DDDDASYCTE SSFRSHSTYS STPGRRKPRV HRPRSPILEE KDIPPLEFPK SSEDLMVPNE
HIMNVIAIYE VLRNFGTVLR LSPFRFEDFC AALVSQEQCT LMAEMHVVLL KAVLREEDTS
NTTFGPADLK DSVNSTLYFI DGMTWPEVLR VYCESDKEYH HVLPYQEAED YPYGPVENKI
KVLQFLVDQF LTTNIAREEL MSEGVIQYDD HCRVCHKLGD LLCCETCSAV YHLECVKPPL
EEVPEDEWQC EVCVAHKVPG VTDCVAEIQK NKPYIRHEPI GYDRSRRKYW FLNRRLIIEE
DTENENEKKI WYYSTKVQLA ELIDCLDKDY WEAELCKILE EMREEIHRHM DITEDLTNKA
RGSNKSFLAA ANEEILESIR VKKGDIDNVK SPEETEKDKN ETENDSKDAE KSREEFEDQS
LEKDSDDKTP DDDPEQGKSE EPTEVGDKGN SVSANLGDNT TNASSEETSP SEGRSPVGCL
SETPDSSNMA EKKVASELPQ DVPGDFKLEK SNGELSESPG AGKGSSGSTR IITRLRNPDS
KLSQLKSQQV AAAAHEANKL FKEGKEVLVV NSQGEISRLS TKKEVVMKGN INNYFKLGQE
GKYRVYHNQY STNSFALNKH QHREDHDKRR HLAHKFCLTP AGEFKWNGSV HGSKVLTIST
LRLTITQLEN NIPSSFLHPN WASHRANWIK AVQMCSKPRE FALALAILEC AVKPVVMLPI
WRESLGHTRL HRMTSIEREE KEKVKKKEKK QEEEETMQQA TWVKYTFPVK HQVWKQKGEE
YRVTGYGGWS WISKTHVYRF VPKLPGNTNV NYRKSLEGTK NNMDENMDES DKRKCSRSPK
KIKTEPDSEK DEVKDSDAAK GADQSEMDIS KITEKKDQDV KELLDSDSDK PCKEEPMEID
DDMKTESHVN CQESSQVDVV NVSEGFHLRT SYKKKTKSSK LDGLLERRIK QFTLEEKQRL
EKIKLEGGIK GIGKTSTNSS KNLSESPVIT KAKEGCQSDS MRQEQSPNAN NDRPEDLIPG
CSESDSSVLG MRDPSRTTNK LYPKDQVLDD VSFRSPETNC QKENSVENDI EENASDPARK
GQEPSKSRTK GNGIFIDDSK LANAGDIGSL IYRNEKLLIQ EENDTIVSSS KSALHSSVPK
STNDRDATPL SKAMDFEGKL GCDSESNSTL ENSSDTVSIH DSSEEDMIVQ NSNESISEQF
RTQEQGIEGL EPLKCELVSE KSTGNCEDRL LGKVTEANGK KTSQQKKLEE RSVNKCSDQI
KLKNTTDKKN NENRESEKKG QRTSTFQING KDNKPKIYLK GECLKEISES KVVSGNVEPK
VNNINKIIPE NDIKSLTVKE SAVRPFINGD VIMEDFNERN SSETKSHLLS SSDAEGNYRD
SLETLPSTKE SDGTQTTTPS PSCPESNSVN QVEDMEIETS EVKKGSSSPV TSGEESNLSN
DFIDENGLPV NKNENVNGES KRKTVITEVT TMTSTVATES KTVIKVEKGD KQTVVSSTEN
CAKSTVTTTT TTVTKLSTPS TGSSVDIISV KEQSKTVVTT TVTDSLTTTG GTLVTSMTVS
KEYSTRDKVK LMKFSRPKKT RSGTALPSYR KFVTKSSKKS IFVLPNDDLK KLARKGGIRE
VPYFNYNAKP ALDIWPYPSP RPTFGITWRY RLQTVKSLAG VSLMLRLLWA SLRWDDMAAK
APPGGGTTRT ETSETEITTT EIIKRRDVGP YGIRSEYCIR KIICPIGVPE TPKETPTPQR
KGLRSSALRP KRPETPKQTG PVIIETWVAE EELELWEIRA FAERVEKEKA QAVEQQAKKR
LEQQKPTVIA TSTTSPTNST TSTISPAQKV MVAPISGSVT TGTKMVLTTK VGSPATVTFQ
QNKNFHQTFA TWVKQGQSNS ATSTAATSAT TIASTGQTFQ ITGNPVTMAG KVITKLPLPA
NSKIVAVNVP ATQGGVVQVQ QKVLGIIPSS TGTSQQTFTS FQPRTATVTI RPNTSGSGGT
TSNSQVITGP QIRPGMTVIR TPLQQSTLGK AIIRTPVMVQ PGAPQQVMTQ IIRGQPVSTA
ISAPNTVSST PGQKSLTSAT STSNIQSSAS QPPRPQQGQV KLTMAQLTQL TQGHGGNQGL
TVVIQGQGQT TGQLQLIPQG VTVLPGPGQQ LMQAAMPNGT VQRFLFTPLA TTATTASTTT
TTVSTTAAGT GEQRQSKLSP QTQVHQDKTL PAAQSSSVGP AEAQPQTAQP SAQPQPQTQP
QSPAQPEVQT QPEVQTQTTV SSHVPSEAQP TQAQSSKPQV AAQSQPQSNV QGQSPVRVQS
PSQARIRPST PSQLSPGQQS QVQTTTSQPI PIQPHTSLQI PSQGQPQSQP QVQSSTQTLS
SGQTLNQVTV SSPSRPQLQI QQPQPQVIAV PQLQQQVQVL SQIQSQVVAQ IQAQQSGVPQ
QIKLQLPIQI QQSNAVQTHQ IQNVVTVQAA SVQEQLQRVQ QLRDQQQKKK QQQIEIKREH
TLQASNQSEI IQKQVVMKHN AVIEHLKQKK SMTPAEREEN QRMIVCNQVM KYILDKIDKE
EKQAAKKRKR EESVEQKRSK QNATKLSALL FKHKEQLRAE ILKKRALLDK DLQIEVQEEL
KRDLKIKKEK DLMQVAQSTA VAVPCPPVTA APPAPPAPPP SPPPPPAVQH TGLLSTPTFP
AASQKRKREE EKDSSSKSKK KKMISTTSKE TKKDTKLYCI CKTPYDESKF YIGCDLCTNW
YHGECVGITE KEAKKMDVYI CNDCKRAQEG SSEELYCICR TPYDESQFYI GCDRCQNWYH
GRCVGILQSE AELIDEYVCP QCQSTEDAMT VLTPLTEKDY EGLKRVLRSL QAHKMAWPFL
EPVDPNDAPD YYGVIKEPMD LATMEERVQR RYYEKLTEFV ADMTKIFDNC RYYNPSDSPF
YQCAEVLESF FVQKLKGFKA SRSHNNKLQS TAS
//
