ID F6ZXB8_CIOIN Unreviewed; 435 AA.
AC F6ZXB8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000014086.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000014086.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01002950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6ZXB8; -.
DR STRING; 7719.ENSCINP00000014086; -.
DR Ensembl; ENSCINT00000014086.3; ENSCINP00000014086.3; ENSCING00000006859.3.
DR GeneTree; ENSGT00940000159290; -.
DR HOGENOM; CLU_045486_0_0_1; -.
DR InParanoid; F6ZXB8; -.
DR OMA; SQINTHG; -.
DR Proteomes; UP000008144; Chromosome 9.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46478; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A; 1.
DR PANTHER; PTHR46478:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 194..389
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 49717 MW; 5D0FDEA0FF94D12C CRC64;
MNRQEAETTK ALAWKVSNRN ASLPPTPYKS QSTDEETSSN RPQSSKKSRR PQKETFYTED
KNSVGVVYKK YPKKKSVRKA VPEPIFPQME ERITSKQWLR KYGIKKMKLD LNRYVSGPVC
IHKKARSKNV TSKWFCSIFP SVDIDGQVRH IDMQESEMVE YEKHVVTLIR RYLTRMQWLL
SGSRKMFGSI LESNVVILID VSGSMSYNMD ELKKEITSLI WEQLNGNKTA FNIVAFSNTS
TKWQDSITES NQSACHDAVQ WVSALTAHGG SATLKAIQVA LADEEAEAIY LLTDGKPDSS
IKLTLSEASN LNKKNIPIHT ISFNCDNREA NDFLKSLSSN SGGRFHRCHG EADAQFAIHR
LMQDECFDED DPNLPSFQGD DLKRLNDEVN KARKFLTQSR RFKSIIQEHE AETRKEQEPP
SPLPNKWISD KPFLP
//
