ID F6ZXK7_XENTR Unreviewed; 1577 AA.
AC F6ZXK7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Mucin 6, oligomeric mucus/gel-forming {ECO:0000313|Ensembl:ENSXETP00000040980};
GN Name=muc6 {ECO:0000313|Ensembl:ENSXETP00000040980};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000040980};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000040980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000040980};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000040980}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR Ensembl; ENSXETT00000040980; ENSXETP00000040980; ENSXETG00000018869.
DR AGR; Xenbase:XB-GENE-987881; -.
DR Xenbase; XB-GENE-987881; muc6.
DR eggNOG; KOG1216; Eukaryota.
DR HOGENOM; CLU_000076_2_1_1; -.
DR TreeFam; TF300299; -.
DR Bgee; ENSXETG00000018869; Expressed in stomach and 1 other cell type or tissue.
DR ExpressionAtlas; F6ZXK7; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF264; MUCIN-6; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 3.
DR SMART; SM00832; C8; 3.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1577
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169767"
FT DOMAIN 88..257
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 438..612
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 908..1077
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1477..1565
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1241..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1334..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1491..1540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 1577 AA; 170960 MW; 1E116B5139207BEE CRC64;
MIFSFLLCFS IVLGSTAGGH NARNSAANSY YRSGSSINTN LGFQRHLVRL INNTKNPAEK
EYDSYKSEYL LRKYEVAPAN FSRCSDKGIC STWGANHFFT FDNDLYQFSG SCNYVLATVC
QSTTPEFNIQ VQRSGGASIT RIIIQIGLIN VVVQGSTTVV LGRTIALPYT ANGIEITKTG
AVTRLYAKQK DFELIVTWST DGNLMVEVDQ RFMNRICGLC GNYNGIPKDD FMVDGKLAMP
YQFANLHQID DPGVTCPFQV PPGKTAPKKS YTEECYSLLK KVSSSCSVSR IPFLKLCQLD
MQSCARPGDA SCVCATLAQY SMRCAMCNQP INNWRTKQLC PLEACPANQI YRECAAPCSP
TCSNPTYTCS SHCVHGCFCP PGTVLDDLSK NLTCVPVSQC PCVVNGKRYY PGERIKSDCS
DCKCHMGQWS CTSTPCPGRC SLEGGSFVTT FDTNMYRFHG DCVYILVTNR NPDNQWTIMA
TFEKCGTSST ETCLESIIYT ASTGAIVMSK EDHITVDSQI KQLPFNSEEV NVIRVSSTNF
ALSTKFGLEI VIHRAPVLNV YIKMSRSYFG TTKGLCGNFN GETMDDFMSS SGVIEGTIPI
FVDSWKAASN CLPAQNSDVN PCSLSYSNEN YAKSHCSALM NSNSPFAACS ALVNLDQYYT
KCVYEACNYQ ETNNFICSAM ASYARACAAK GVILQNWRES TNCTVQCPGN QTYSYNTTSC
GRTCLSLSNK ELECYPNDIP VEGCNCPTGF YLDNKNMCVR KESCPCYLDA NTILLPQQQT
TYNGLTCICS SGSLNCIGFL QAAQESCPAP KMMKTCDSLT DKYGAACAPT CQLLATGISC
IPTKCVSGCV CPSGTYEDLD GNCVNQTDCS CEFGGEIYKT GDTMQSECQS CTCNGGHWNC
EANLNCASTC VLYGESHIKT FDGQQFVFEG NCEYTLVTDG CGVNNSLSSF KIVSENVVCG
TTGVTCSRAI TAFIGDTTLK MFDEKYTVTG VNDIKVLNNT LFIEFVITIP HKFKISILWN
KDMNVFIKVF KLGKQSVCGL CGNYNGNVKD DYQTRSKYVT SNALDFINSW KESPMCNNVR
LIVSPCDANP HRKPWATSSC SIINSQTFDA CHKVVNSQLY YESCVNDACG CDTGGDCTCM
CDAVQAYAKA CLAAGVCVDW RTPDFCPVYC DYKNTHVSTG DGYVYSPDVN CTWHYQPCQC
PFALQAYPHQ NFEGCYQCGP DKYFDPEQNT CLPCVEHSTT TIEPSTSGTS VSTPATTPVP
TSATATTVST PGTTPVSTSV TTTSVSTPVT TPVSSSATAT SVSSSPPVTI TTIKPTEITS
TRITTVTPKP STSVIVKTTP TTSTTLSKTT STSHMASTKF PTSQTTHPSS SLASTISTTT
NPPVTTTKTT PPVSTTNMTV TPVTSESTTT VTSTATTTET KHTEATHTTT ISNSSPSITV
TFPVTSSTPK ENTTTHHTTP HVTAPDQPST STPASVCSIQ QYQHTITQNG CSANVTLTKC
HGYCESESWY NDDFTSVEEN CGCCAPQLNT AQSKDVDLKC PNATKSVTVT IKIFKECICN
YKPCANSAKA NPGKALA
//
