ID F6ZXR9_XENTR Unreviewed; 570 AA.
AC F6ZXR9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Cryptochrome 4 {ECO:0000313|Ensembl:ENSXETP00000033570};
GN Name=cry4 {ECO:0000313|Ensembl:ENSXETP00000033570};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000033570};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000033570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000033570};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000033570}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000256|ARBA:ARBA00005862}.
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DR AlphaFoldDB; F6ZXR9; -.
DR STRING; 8364.ENSXETP00000033570; -.
DR PaxDb; 8364-ENSXETP00000002924; -.
DR Ensembl; ENSXETT00000033570; ENSXETP00000033570; ENSXETG00000015354.
DR AGR; Xenbase:XB-GENE-978401; -.
DR Xenbase; XB-GENE-5945160; cry4.
DR HOGENOM; CLU_010348_3_4_1; -.
DR InParanoid; F6ZXR9; -.
DR OrthoDB; 2919077at2759; -.
DR Bgee; ENSXETG00000015354; Expressed in testis and 12 other cell types or tissues.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR PANTHER; PTHR11455:SF61; CRYPTOCHROME-LIKE PROTEIN; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW 1}.
FT DOMAIN 16..146
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT BINDING 260..264
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 301..308
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 399..401
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT SITE 332
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 386
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 409
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
SQ SEQUENCE 570 AA; 66139 MW; C0E7F55A3D2E0ABE CRC64;
MYKSSIRFRS CSTMPHRTIH IFRKGLRLHD NPTLVTALET SDVVYPVYIL DRNFMTSSSV
IGSKRWNFFL QSIEDLHCNL QKLNSCLFVI QGDYERVLRE HVEKWNITQV TFDLEIEPYY
KGLDERIRAM GQELGFEVVS MVAHTLYDIK TILALNCGKP PLTYKNFLRV LSMIGNPDKP
ARQITSEDFI KCITPTKLAA EEYYRIPKPE DLGISKDCPT NWVGGESEAL SRLEQHLEKQ
GWVANFKKPQ TIPNSLLPST TGLSPYFSLG CLSVRVFFHR LSNIYAQSKN HSLPPVSLQG
QLLWREFFYT VASSTPNFTH MVGNPICLQI DWYKNEEQLQ KWKEAKTGFP WIDAIMTQLH
NEGWIHHLAR HAVACFLTRG DLWISWEEGM KVFEEFLLDA DYCINAGNWM WLSASAFFHH
YTRIFCPVRF GRRSDPEGNY IRKYLPVLKN FPAKYIYEPW TAPEEIQKQA GCLIGKDYPL
PMVDHKTASE HNLQLMRQVR EEQQKTAQLT KDIADDPMEL NLKHPFKNDK ECGLENNKVK
RRCLEEMTAE DGTRQSDLVQ SLDPCEVKVC
//
